A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?

We present a case of a patient who had a history of severe coronavirus disease (COVID-19) 4 months prior to this current presentation and, after a long asymptomatic period, subsequently tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by a RNA PCR assay, after several...

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Detalles Bibliográficos
Autores principales: Tuan, Jessica, Spichler-Moffarah, Anne, Ogbuagu, Onyema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098910/
https://www.ncbi.nlm.nih.gov/pubmed/33542020
http://dx.doi.org/10.1136/bcr-2020-240531
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author Tuan, Jessica
Spichler-Moffarah, Anne
Ogbuagu, Onyema
author_facet Tuan, Jessica
Spichler-Moffarah, Anne
Ogbuagu, Onyema
author_sort Tuan, Jessica
collection PubMed
description We present a case of a patient who had a history of severe coronavirus disease (COVID-19) 4 months prior to this current presentation and, after a long asymptomatic period, subsequently tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by a RNA PCR assay, after several interval negative SARS-CoV-2 RNA tests. We present this potential case of SARS-CoV-2 reinfection in order to incite discussion around differentiating persistent infection with intermittent viral shedding and reinfection, as well as to discuss evolving knowledge and approaches to the clinical management, follow-up molecular testing and treatment of COVID-19 reinfection.
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spelling pubmed-80989102021-05-18 A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding? Tuan, Jessica Spichler-Moffarah, Anne Ogbuagu, Onyema BMJ Case Rep Case Report We present a case of a patient who had a history of severe coronavirus disease (COVID-19) 4 months prior to this current presentation and, after a long asymptomatic period, subsequently tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by a RNA PCR assay, after several interval negative SARS-CoV-2 RNA tests. We present this potential case of SARS-CoV-2 reinfection in order to incite discussion around differentiating persistent infection with intermittent viral shedding and reinfection, as well as to discuss evolving knowledge and approaches to the clinical management, follow-up molecular testing and treatment of COVID-19 reinfection. BMJ Publishing Group 2021-01-20 /pmc/articles/PMC8098910/ /pubmed/33542020 http://dx.doi.org/10.1136/bcr-2020-240531 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Tuan, Jessica
Spichler-Moffarah, Anne
Ogbuagu, Onyema
A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
title A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
title_full A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
title_fullStr A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
title_full_unstemmed A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
title_short A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
title_sort new positive sars-cov-2 test months after severe covid-19 illness: reinfection or intermittent viral shedding?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098910/
https://www.ncbi.nlm.nih.gov/pubmed/33542020
http://dx.doi.org/10.1136/bcr-2020-240531
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