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Expanded antigen-experienced CD160(+)CD8(+)effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia

BACKGROUND: T cell exhaustion compromises antitumor immunity, and a sustained elevation of co-inhibitory receptors is a hallmark of T cell exhaustion in solid tumors. Similarly, upregulation of co-inhibitory receptors has been reported in T cells in hematological cancers such as chronic lymphocytic...

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Detalles Bibliográficos
Autores principales:	Bozorgmehr, Najmeh, Okoye, Isobel, Oyegbami, Olaide, Xu, Lai, Fontaine, Amelie, Cox-Kennett, Nanette, Larratt, Loree M, Hnatiuk, Mark, Fagarasanu, Andrei, Brandwein, Joseph, Peters, Anthea C, Elahi, Shokrollah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098955/ https://www.ncbi.nlm.nih.gov/pubmed/33931471 http://dx.doi.org/10.1136/jitc-2020-002189

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