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Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo

CircRNAs have been reported to play essential roles in regulating immunity and inflammation, which may be an important regulatory factor in the development of vitiligo. However, the expression profile of circRNAs and their potential biological functions in vitiligo have not been reported so far. In...

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Autores principales: Li, Lili, Xie, Zhi, Qian, Xiliang, Wang, Tai, Jiang, Minmin, Qin, Jinglin, Wang, Chen, Wu, Rongqun, Song, Canling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098995/
https://www.ncbi.nlm.nih.gov/pubmed/33968138
http://dx.doi.org/10.3389/fgene.2021.663091
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author Li, Lili
Xie, Zhi
Qian, Xiliang
Wang, Tai
Jiang, Minmin
Qin, Jinglin
Wang, Chen
Wu, Rongqun
Song, Canling
author_facet Li, Lili
Xie, Zhi
Qian, Xiliang
Wang, Tai
Jiang, Minmin
Qin, Jinglin
Wang, Chen
Wu, Rongqun
Song, Canling
author_sort Li, Lili
collection PubMed
description CircRNAs have been reported to play essential roles in regulating immunity and inflammation, which may be an important regulatory factor in the development of vitiligo. However, the expression profile of circRNAs and their potential biological functions in vitiligo have not been reported so far. In our study we found there are 64 dysregulated circRNAs and 14 dysregulated miRNAs in the patients with vitiligo. Through the correlation analysis, we obtained 12 dysregulated circRNAs and 5 dysregulated miRNAs, forming 48 relationships in the circRNA-miRNA-mRNA regulatory network. Gene Ontology analysis indicated dysregulated circRNAs in vitiligo is closely related to the disorder of the metabolic pathway. The KEGG pathway of dysregulation of circRNAs mainly enriched in the biological processes such as ubiquitin mediated proteolysis, endocytosis and RNA degradation, and in Jak-STAT signaling pathway. Therefore, we found the circRNA-miRNA-mRNA regulatory network are involved in the regulation of numerous melanocyte functions, and these dysregulated circRNAs may closely related to the melanocyte metabolism. Our study provides a theoretical basis for studying the vitiligo pathogenesis from the perspective of circRNA-miRNA-mRNA network.
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spelling pubmed-80989952021-05-06 Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo Li, Lili Xie, Zhi Qian, Xiliang Wang, Tai Jiang, Minmin Qin, Jinglin Wang, Chen Wu, Rongqun Song, Canling Front Genet Genetics CircRNAs have been reported to play essential roles in regulating immunity and inflammation, which may be an important regulatory factor in the development of vitiligo. However, the expression profile of circRNAs and their potential biological functions in vitiligo have not been reported so far. In our study we found there are 64 dysregulated circRNAs and 14 dysregulated miRNAs in the patients with vitiligo. Through the correlation analysis, we obtained 12 dysregulated circRNAs and 5 dysregulated miRNAs, forming 48 relationships in the circRNA-miRNA-mRNA regulatory network. Gene Ontology analysis indicated dysregulated circRNAs in vitiligo is closely related to the disorder of the metabolic pathway. The KEGG pathway of dysregulation of circRNAs mainly enriched in the biological processes such as ubiquitin mediated proteolysis, endocytosis and RNA degradation, and in Jak-STAT signaling pathway. Therefore, we found the circRNA-miRNA-mRNA regulatory network are involved in the regulation of numerous melanocyte functions, and these dysregulated circRNAs may closely related to the melanocyte metabolism. Our study provides a theoretical basis for studying the vitiligo pathogenesis from the perspective of circRNA-miRNA-mRNA network. Frontiers Media S.A. 2021-04-21 /pmc/articles/PMC8098995/ /pubmed/33968138 http://dx.doi.org/10.3389/fgene.2021.663091 Text en Copyright © 2021 Li, Xie, Qian, Wang, Jiang, Qin, Wang, Wu and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Lili
Xie, Zhi
Qian, Xiliang
Wang, Tai
Jiang, Minmin
Qin, Jinglin
Wang, Chen
Wu, Rongqun
Song, Canling
Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo
title Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo
title_full Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo
title_fullStr Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo
title_full_unstemmed Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo
title_short Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo
title_sort identification of a potentially functional circrna-mirna-mrna regulatory network in melanocytes for investigating pathogenesis of vitiligo
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098995/
https://www.ncbi.nlm.nih.gov/pubmed/33968138
http://dx.doi.org/10.3389/fgene.2021.663091
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