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The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study

BACKGROUND: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19 illness. However, no study to date has examined the association between CRF and COVID-19. The objectives of this study were to determine whether CRF is independen...

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Autores principales: Christensen, Rebecca A. G., Arneja, Jasleen, St. Cyr, Kate, Sturrock, Shelby L., Brooks, Jennifer D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099071/
https://www.ncbi.nlm.nih.gov/pubmed/33951071
http://dx.doi.org/10.1371/journal.pone.0250508
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author Christensen, Rebecca A. G.
Arneja, Jasleen
St. Cyr, Kate
Sturrock, Shelby L.
Brooks, Jennifer D.
author_facet Christensen, Rebecca A. G.
Arneja, Jasleen
St. Cyr, Kate
Sturrock, Shelby L.
Brooks, Jennifer D.
author_sort Christensen, Rebecca A. G.
collection PubMed
description BACKGROUND: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19 illness. However, no study to date has examined the association between CRF and COVID-19. The objectives of this study were to determine whether CRF is independently associated with testing positive with or dying from COVID-19. METHODS: This is a prospective cohort study of 2,690 adults from the UK Biobank Study that were followed from March 16(th), 2020 to July 26(th), 2020. Participants who were tested for COVID-19 and had undergone CRF assessment were examined. CRF was estimated (eCRF) and categorized as low (<20(th) percentile), moderate (20(th) to 80(th) percentile) and high (≥80(th) percentile) within sex and ten-year age groups (e.g. 50–60 years). Participants were classified as having COVID-19 if they tested positive (primarily PCR tests) at an in-patient or out-patient setting as of July 26, 2020. Participants were classified as having died from COVID-19 if the primary or underlying cause of death was listed ICD-10 codes U071 or U072 by June 30(th), 2020. Adjusted risk ratios (aRR) and 95% confidence intervals (CI) were estimated and a forward model building approach used to identify covariates. FINDINGS: There was no significant association between eCRF and testing positive for COVID-19. Conversely, individuals with moderate (aRR = 0.43, 95% CI: 0.25, 0.75) and high fitness (aRR = 0.37, 95% CI: 0.16, 0.85) had a significantly lower risk of dying from COVID-19 than those with low fitness. CONCLUSIONS: While eCRF was not significantly associated with testing positive for COVID-19, we observed a significant dose-response between having higher eCRF and a decreased risk of dying from COVID-19. This suggests that prior gains in CRF could be protective against dying from COVID-19 should someone develop the virus.
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spelling pubmed-80990712021-05-17 The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study Christensen, Rebecca A. G. Arneja, Jasleen St. Cyr, Kate Sturrock, Shelby L. Brooks, Jennifer D. PLoS One Research Article BACKGROUND: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19 illness. However, no study to date has examined the association between CRF and COVID-19. The objectives of this study were to determine whether CRF is independently associated with testing positive with or dying from COVID-19. METHODS: This is a prospective cohort study of 2,690 adults from the UK Biobank Study that were followed from March 16(th), 2020 to July 26(th), 2020. Participants who were tested for COVID-19 and had undergone CRF assessment were examined. CRF was estimated (eCRF) and categorized as low (<20(th) percentile), moderate (20(th) to 80(th) percentile) and high (≥80(th) percentile) within sex and ten-year age groups (e.g. 50–60 years). Participants were classified as having COVID-19 if they tested positive (primarily PCR tests) at an in-patient or out-patient setting as of July 26, 2020. Participants were classified as having died from COVID-19 if the primary or underlying cause of death was listed ICD-10 codes U071 or U072 by June 30(th), 2020. Adjusted risk ratios (aRR) and 95% confidence intervals (CI) were estimated and a forward model building approach used to identify covariates. FINDINGS: There was no significant association between eCRF and testing positive for COVID-19. Conversely, individuals with moderate (aRR = 0.43, 95% CI: 0.25, 0.75) and high fitness (aRR = 0.37, 95% CI: 0.16, 0.85) had a significantly lower risk of dying from COVID-19 than those with low fitness. CONCLUSIONS: While eCRF was not significantly associated with testing positive for COVID-19, we observed a significant dose-response between having higher eCRF and a decreased risk of dying from COVID-19. This suggests that prior gains in CRF could be protective against dying from COVID-19 should someone develop the virus. Public Library of Science 2021-05-05 /pmc/articles/PMC8099071/ /pubmed/33951071 http://dx.doi.org/10.1371/journal.pone.0250508 Text en © 2021 Christensen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Christensen, Rebecca A. G.
Arneja, Jasleen
St. Cyr, Kate
Sturrock, Shelby L.
Brooks, Jennifer D.
The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
title The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
title_full The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
title_fullStr The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
title_full_unstemmed The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
title_short The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study
title_sort association of estimated cardiorespiratory fitness with covid-19 incidence and mortality: a cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099071/
https://www.ncbi.nlm.nih.gov/pubmed/33951071
http://dx.doi.org/10.1371/journal.pone.0250508
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