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Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism

During the glyoxylate cycle, isocitrate lyases (ICLs) catalyze the lysis of isocitrate to glyoxylate and succinate. Itaconate has been reported to inhibit an ICL from Mycobacterium tuberculosis (tbICL). To elucidate the molecular mechanism of ICL inhibition, we determined the crystal structure of tb...

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Detalles Bibliográficos
Autores principales:	Kwon, Sunghark, Chun, Hye Lin, Ha, Hyun Ji, Lee, So Yeon, Park, Hyun Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099091/ https://www.ncbi.nlm.nih.gov/pubmed/33951112 http://dx.doi.org/10.1371/journal.pone.0251067

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