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Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells

The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have laid a sound foundation for their clinical application in various diseases. However, the clinical efficiency of MSC treatments varies depending on certain cell characteristics. Among these, the roles of cell aging...

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Detalles Bibliográficos
Autores principales: Yin, Min, Zhang, Yan, Yu, Haibo, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099107/
https://www.ncbi.nlm.nih.gov/pubmed/33968939
http://dx.doi.org/10.3389/fcell.2021.665412
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author Yin, Min
Zhang, Yan
Yu, Haibo
Li, Xia
author_facet Yin, Min
Zhang, Yan
Yu, Haibo
Li, Xia
author_sort Yin, Min
collection PubMed
description The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have laid a sound foundation for their clinical application in various diseases. However, the clinical efficiency of MSC treatments varies depending on certain cell characteristics. Among these, the roles of cell aging or senescence cannot be excluded. Despite their stemness, evidence of senescence in MSCs has recently gained attention. Many factors may contribute to the senescence of MSCs, including MSC origin (biological niche), donor conditions (age, obesity, diseases, or unknown factors), and culture conditions in vitro. With the rapidly increasing prevalence of diabetes mellitus (DM) and gestational diabetes mellitus (GDM), the effects of hyperglycemia on the senescence of MSCs should be evaluated to improve the application of autologous MSCs. This review aims to present the available data on the senescence of MSCs, its relationship with hyperglycemia, and the strategies to suppress the senescence of MSCs in a hyperglycemic environment.
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spelling pubmed-80991072021-05-06 Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells Yin, Min Zhang, Yan Yu, Haibo Li, Xia Front Cell Dev Biol Cell and Developmental Biology The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have laid a sound foundation for their clinical application in various diseases. However, the clinical efficiency of MSC treatments varies depending on certain cell characteristics. Among these, the roles of cell aging or senescence cannot be excluded. Despite their stemness, evidence of senescence in MSCs has recently gained attention. Many factors may contribute to the senescence of MSCs, including MSC origin (biological niche), donor conditions (age, obesity, diseases, or unknown factors), and culture conditions in vitro. With the rapidly increasing prevalence of diabetes mellitus (DM) and gestational diabetes mellitus (GDM), the effects of hyperglycemia on the senescence of MSCs should be evaluated to improve the application of autologous MSCs. This review aims to present the available data on the senescence of MSCs, its relationship with hyperglycemia, and the strategies to suppress the senescence of MSCs in a hyperglycemic environment. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8099107/ /pubmed/33968939 http://dx.doi.org/10.3389/fcell.2021.665412 Text en Copyright © 2021 Yin, Zhang, Yu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yin, Min
Zhang, Yan
Yu, Haibo
Li, Xia
Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells
title Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells
title_full Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells
title_fullStr Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells
title_full_unstemmed Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells
title_short Role of Hyperglycemia in the Senescence of Mesenchymal Stem Cells
title_sort role of hyperglycemia in the senescence of mesenchymal stem cells
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099107/
https://www.ncbi.nlm.nih.gov/pubmed/33968939
http://dx.doi.org/10.3389/fcell.2021.665412
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