Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic leth...

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Detalles Bibliográficos
Autores principales: Dinh, Tra Thi Huong, Iseki, Hiroyoshi, Mizuno, Seiya, Iijima-Mizuno, Saori, Tanimoto, Yoko, Daitoku, Yoko, Kato, Kanako, Hamada, Yuko, Hasan, Ammar Shaker Hamed, Suzuki, Hayate, Murata, Kazuya, Muratani, Masafumi, Ema, Masatsugu, Kim, Jun-Dal, Ishida, Junji, Fukamizu, Akiyoshi, Kato, Mitsuyasu, Takahashi, Satoru, Yagami, Ken-ichi, Wilson, Valerie, Arkell, Ruth M, Sugiyama, Fumihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099427/
https://www.ncbi.nlm.nih.gov/pubmed/33949947
http://dx.doi.org/10.7554/eLife.50346

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