Cargando…

Structural determinants of voltage-gating properties in calcium channels

Voltage-gated calcium channels control key functions of excitable cells, like synaptic transmission in neurons and the contraction of heart and skeletal muscles. To accomplish such diverse functions, different calcium channels activate at different voltages and with distinct kinetics. To identify th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Quintero, Monica L, El Ghaleb, Yousra, Tuluc, Petronel, Campiglio, Marta, Liedl, Klaus R, Flucher, Bernhard E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099428/ https://www.ncbi.nlm.nih.gov/pubmed/33783354 http://dx.doi.org/10.7554/eLife.64087

Ejemplares similares

Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca(V)1.1 gating
por: El Ghaleb, Yousra, et al.
Publicado: (2021)

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?
por: Flucher, Bernhard E., et al.
Publicado: (2017)

Role of putative voltage-sensor countercharge D4 in regulating gating properties of Ca(V)1.2 and Ca(V)1.3 calcium channels
por: Costé de Bagneaux, Pierre, et al.
Publicado: (2018)

Correcting the R165K substitution in the first voltage-sensor of Ca(V)1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation
por: El Ghaleb, Yousra, et al.
Publicado: (2019)

The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels
por: Campiglio, Marta, et al.
Publicado: (2015)

Calcium current modulation by the γ(1) subunit depends on alternative splicing of Ca(V)1.1
por: El Ghaleb, Yousra, et al.
Publicado: (2022)

Structural insights into binding of STAC proteins to voltage-gated calcium channels
por: Wong King Yuen, Siobhan M., et al.
Publicado: (2017)

CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders
por: El Ghaleb, Yousra, et al.
Publicado: (2021)

Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in Ca(V)1.1 calcium channels
por: Tuluc, Petronel, et al.
Publicado: (2016)

Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation
por: Flucher, Bernhard E.
Publicado: (2016)

STAC proteins associate to the IQ domain of Ca(V)1.2 and inhibit calcium-dependent inactivation
por: Campiglio, Marta, et al.
Publicado: (2018)

Correction: Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation
por: Flucher, Bernhard E.
Publicado: (2016)

Mechanisms Responsible for ω-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains
por: Monteleone, Stefania, et al.
Publicado: (2017)

Physiological and Pharmacological Modulation of the Embryonic Skeletal Muscle Calcium Channel Splice Variant Ca(V)1.1e
por: Benedetti, Bruno, et al.
Publicado: (2015)

Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of Ca(V)1.3 Channels
por: del Rivero Morfin, Pedro J., et al.
Publicado: (2023)

Stapled Voltage-Gated Calcium Channel (Ca(V)) α-Interaction Domain (AID) Peptides Act As Selective Protein–Protein Interaction Inhibitors of Ca(V) Function
por: Findeisen, Felix, et al.
Publicado: (2017)

Role of High Voltage-Gated Ca(2+) Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function
por: Tuluc, Petronel, et al.
Publicado: (2021)

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations
por: Yang, Zheng Fang, et al.
Publicado: (2022)

Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder
por: Hofer, Nadja T., et al.
Publicado: (2020)

The juvenile myoclonic epilepsy mutant of the calcium channel β(4) subunit displays normal nuclear targeting in nerve and muscle cells
por: Etemad, Solmaz, et al.
Publicado: (2014)

CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels
por: Pinggera, Alexandra, et al.
Publicado: (2015)

Optogenetic Control of Voltage‐Gated Calcium Channels
por: Ma, Guolin, et al.
Publicado: (2018)

Functions of Presynaptic Voltage-gated Calcium Channels
por: Dolphin, Annette C
Publicado: (2020)

RGK regulation of voltage-gated calcium channels
por: Zafir, BURAEI, et al.
Publicado: (2015)

Splice variants of the Ca(V)1.3 L-type calcium channel regulate dendritic spine morphology
por: Stanika, Ruslan, et al.
Publicado: (2016)

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca(2+) channel activators
por: Ortner, Nadine J., et al.
Publicado: (2014)

Calmodulin regulation (calmodulation) of voltage-gated calcium channels
por: Ben-Johny, Manu, et al.
Publicado: (2014)

Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
por: Kushner, Jared, et al.
Publicado: (2019)

How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity
por: Frank, C. Andrew
Publicado: (2014)

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated Ca(V)1.2 Calcium Channel Function
por: Kaur, Gurjot, et al.
Publicado: (2015)

STAC3 stably interacts through its C1 domain with Ca(V)1.1 in skeletal muscle triads
por: Campiglio, Marta, et al.
Publicado: (2017)

LRRK2 Regulates Voltage-Gated Calcium Channel Function
por: Bedford, Cade, et al.
Publicado: (2016)

Voltage‐gated calcium channels – from basic mechanisms to disease
por: Striessnig, Jörg
Publicado: (2016)

Voltage-Gated Calcium Channel Antagonists and Traumatic Brain Injury
por: Gurkoff, Gene, et al.
Publicado: (2013)

Voltage-gated calcium channels: Novel targets for cancer therapy
por: Phan, Nam Nhut, et al.
Publicado: (2017)

β subunits of voltage-gated calcium channels in cardiovascular diseases
por: Loh, Kelvin Wei Zhern, et al.
Publicado: (2023)

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
por: Han, Shuo, et al.
Publicado: (2022)

A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions
por: Coste de Bagneaux, Pierre, et al.
Publicado: (2020)

Structural basis for Ca(2+) selectivity of a voltage-gated calcium channel
por: Tang, Lin, et al.
Publicado: (2013)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q6tuat85hlcc6vpi1uur3r2nkb