Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T

Despite tremendous success of chimeric antigen receptor (CAR) T cell therapy in clinical oncology, the dose‐exposure‐response relationship of CAR‐T cells in patients is poorly understood. Moreover, the key drug‐specific and system‐specific determinants leading to favorable clinical outcomes are also...

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Detalles Bibliográficos
Autores principales: Singh, Aman P., Chen, Wenbo, Zheng, Xirong, Mody, Hardik, Carpenter, Thomas J., Zong, Alice, Heald, Donald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099446/
https://www.ncbi.nlm.nih.gov/pubmed/33565700
http://dx.doi.org/10.1002/psp4.12598

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