LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to...

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Autores principales: Yadav, Bhupender, Pal, Sonali, Rubstov, Yury, Goel, Akul, Garg, Manoj, Pavlyukov, Marat, Pandey, Amit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099481/
https://www.ncbi.nlm.nih.gov/pubmed/33996255
http://dx.doi.org/10.1016/j.omtn.2021.03.018
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author Yadav, Bhupender
Pal, Sonali
Rubstov, Yury
Goel, Akul
Garg, Manoj
Pavlyukov, Marat
Pandey, Amit Kumar
author_facet Yadav, Bhupender
Pal, Sonali
Rubstov, Yury
Goel, Akul
Garg, Manoj
Pavlyukov, Marat
Pandey, Amit Kumar
author_sort Yadav, Bhupender
collection PubMed
description Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.
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spelling pubmed-80994812021-05-14 LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics Yadav, Bhupender Pal, Sonali Rubstov, Yury Goel, Akul Garg, Manoj Pavlyukov, Marat Pandey, Amit Kumar Mol Ther Nucleic Acids Review Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes. American Society of Gene & Cell Therapy 2021-04-02 /pmc/articles/PMC8099481/ /pubmed/33996255 http://dx.doi.org/10.1016/j.omtn.2021.03.018 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Yadav, Bhupender
Pal, Sonali
Rubstov, Yury
Goel, Akul
Garg, Manoj
Pavlyukov, Marat
Pandey, Amit Kumar
LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_full LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_fullStr LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_full_unstemmed LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_short LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_sort lncrnas associated with glioblastoma: from transcriptional noise to novel regulators with a promising role in therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099481/
https://www.ncbi.nlm.nih.gov/pubmed/33996255
http://dx.doi.org/10.1016/j.omtn.2021.03.018
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