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The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study
BACKGROUND: Esophageal motility disorders (EMDs) are often diagnosed manometrically, yet the underlying pathology is not always clear. Esophageal function testing (EFT), which incorporates manometry and multichannel intraluminal impedance (MII), is considered a useful tool in the assessment of EMDs....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099495/ https://www.ncbi.nlm.nih.gov/pubmed/33996046 http://dx.doi.org/10.1016/j.amsu.2021.102277 |
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author | Tuma, Faiz Aljazeeri, Jafar Khorgami, Zhamak Khaitan, Leena |
author_facet | Tuma, Faiz Aljazeeri, Jafar Khorgami, Zhamak Khaitan, Leena |
author_sort | Tuma, Faiz |
collection | PubMed |
description | BACKGROUND: Esophageal motility disorders (EMDs) are often diagnosed manometrically, yet the underlying pathology is not always clear. Esophageal function testing (EFT), which incorporates manometry and multichannel intraluminal impedance (MII), is considered a useful tool in the assessment of EMDs. OBJECTIVE: This study aims to assess the most likely level of impaired bolus transit within the esophagus which may help further localize and characterize EMDs. METHODS: In a retrospective study design, we reviewed consecutive EFTs over a period of 12 months. Data included diagnosis, presenting symptoms, and EFT results of liquid and viscous swallows. Each patient underwent 10 liquid and 10 viscous swallows, and bolus transit is measured at 5, 10, 15 and 20 cm above the gastroesophageal junction (GEJ). We recorded the initial level of impaired bolus transit for each swallow. RESULTS: A total of 2358 swallows in 118 patients was included for analysis. Of these, 837 swallows (35.5%) were incompletely transmitted. The proportions of impaired bolus transit were 39%, 41%, 15.6%, 4.4% at 20 cm, 15 cm, 10 cm, and 5 cm above the GEJ, respectively. The common symptoms at presentation were dysphagia (47%), heartburn (44%), chest pain (24.6%) and regurgitation (18%). The mean lower esophageal sphincter (LES) pressure was 24 ± 13.9 mmHg whereas the mean contraction amplitude was 84 ± 46.6 mmHg. CONCLUSION: In patients with abnormal esophageal clearance, the most likely levels of impaired bolus transit are 15 and 20 cm above the GEJ. These levels of the esophagus should be a focus of attention in future studies evaluating the pathophysiology of esophageal dysmotility. |
format | Online Article Text |
id | pubmed-8099495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-80994952021-05-13 The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study Tuma, Faiz Aljazeeri, Jafar Khorgami, Zhamak Khaitan, Leena Ann Med Surg (Lond) Cross-sectional Study BACKGROUND: Esophageal motility disorders (EMDs) are often diagnosed manometrically, yet the underlying pathology is not always clear. Esophageal function testing (EFT), which incorporates manometry and multichannel intraluminal impedance (MII), is considered a useful tool in the assessment of EMDs. OBJECTIVE: This study aims to assess the most likely level of impaired bolus transit within the esophagus which may help further localize and characterize EMDs. METHODS: In a retrospective study design, we reviewed consecutive EFTs over a period of 12 months. Data included diagnosis, presenting symptoms, and EFT results of liquid and viscous swallows. Each patient underwent 10 liquid and 10 viscous swallows, and bolus transit is measured at 5, 10, 15 and 20 cm above the gastroesophageal junction (GEJ). We recorded the initial level of impaired bolus transit for each swallow. RESULTS: A total of 2358 swallows in 118 patients was included for analysis. Of these, 837 swallows (35.5%) were incompletely transmitted. The proportions of impaired bolus transit were 39%, 41%, 15.6%, 4.4% at 20 cm, 15 cm, 10 cm, and 5 cm above the GEJ, respectively. The common symptoms at presentation were dysphagia (47%), heartburn (44%), chest pain (24.6%) and regurgitation (18%). The mean lower esophageal sphincter (LES) pressure was 24 ± 13.9 mmHg whereas the mean contraction amplitude was 84 ± 46.6 mmHg. CONCLUSION: In patients with abnormal esophageal clearance, the most likely levels of impaired bolus transit are 15 and 20 cm above the GEJ. These levels of the esophagus should be a focus of attention in future studies evaluating the pathophysiology of esophageal dysmotility. Elsevier 2021-04-19 /pmc/articles/PMC8099495/ /pubmed/33996046 http://dx.doi.org/10.1016/j.amsu.2021.102277 Text en © 2021 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Cross-sectional Study Tuma, Faiz Aljazeeri, Jafar Khorgami, Zhamak Khaitan, Leena The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study |
title | The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study |
title_full | The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study |
title_fullStr | The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study |
title_full_unstemmed | The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study |
title_short | The level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: Cross-sectional study |
title_sort | level of impaired esophageal bolus transit measured by multichannel intraluminal impedance: cross-sectional study |
topic | Cross-sectional Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099495/ https://www.ncbi.nlm.nih.gov/pubmed/33996046 http://dx.doi.org/10.1016/j.amsu.2021.102277 |
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