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Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode...

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Autores principales: Pham, Thi Hai Yen, Mai, Thi Trang, Nguyen, Hoang Anh, Chu, Thi Thu Hien, Vu, Thi Thu Ha, Le, Quoc Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099507/
https://www.ncbi.nlm.nih.gov/pubmed/34007510
http://dx.doi.org/10.1155/2021/8823452
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author Pham, Thi Hai Yen
Mai, Thi Trang
Nguyen, Hoang Anh
Chu, Thi Thu Hien
Vu, Thi Thu Ha
Le, Quoc Hung
author_facet Pham, Thi Hai Yen
Mai, Thi Trang
Nguyen, Hoang Anh
Chu, Thi Thu Hien
Vu, Thi Thu Ha
Le, Quoc Hung
author_sort Pham, Thi Hai Yen
collection PubMed
description A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode by a chronoamperometry process at 5 V and then an electrochemical reduction process was carried out to form RGOnS with restored long-range conjugated networks and better conductivity. The electrodes were characterized by SEM, EDX, and FTIR spectroscopy. The RGOnS electrode prepared at an optimal reduction potential of −1 V for 120 s exhibits a larger electrochemical active surface area, and the obtained oxidation signal of AMX is approximately ten times higher than that of the pristine graphite electrode. The analytical conditions such as the pH of electrolyte and accumulation time were optimized. The calibration curve built under the optimal conditions provided a good linear relationship in the range of AMX concentration from 0.5–80 µM with the correlation coefficient of 0.9992. The limit of detection was calculated as 0.193 µM. Satisfactory results are obtained from the detection of the AMX in different samples using the prepared electrode.
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spelling pubmed-80995072021-05-17 Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode Pham, Thi Hai Yen Mai, Thi Trang Nguyen, Hoang Anh Chu, Thi Thu Hien Vu, Thi Thu Ha Le, Quoc Hung J Anal Methods Chem Research Article A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode by a chronoamperometry process at 5 V and then an electrochemical reduction process was carried out to form RGOnS with restored long-range conjugated networks and better conductivity. The electrodes were characterized by SEM, EDX, and FTIR spectroscopy. The RGOnS electrode prepared at an optimal reduction potential of −1 V for 120 s exhibits a larger electrochemical active surface area, and the obtained oxidation signal of AMX is approximately ten times higher than that of the pristine graphite electrode. The analytical conditions such as the pH of electrolyte and accumulation time were optimized. The calibration curve built under the optimal conditions provided a good linear relationship in the range of AMX concentration from 0.5–80 µM with the correlation coefficient of 0.9992. The limit of detection was calculated as 0.193 µM. Satisfactory results are obtained from the detection of the AMX in different samples using the prepared electrode. Hindawi 2021-04-28 /pmc/articles/PMC8099507/ /pubmed/34007510 http://dx.doi.org/10.1155/2021/8823452 Text en Copyright © 2021 Thi Hai Yen Pham et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pham, Thi Hai Yen
Mai, Thi Trang
Nguyen, Hoang Anh
Chu, Thi Thu Hien
Vu, Thi Thu Ha
Le, Quoc Hung
Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
title Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
title_full Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
title_fullStr Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
title_full_unstemmed Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
title_short Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
title_sort voltammetric determination of amoxicillin using a reduced graphite oxide nanosheet electrode
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099507/
https://www.ncbi.nlm.nih.gov/pubmed/34007510
http://dx.doi.org/10.1155/2021/8823452
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