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Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode
A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099507/ https://www.ncbi.nlm.nih.gov/pubmed/34007510 http://dx.doi.org/10.1155/2021/8823452 |
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author | Pham, Thi Hai Yen Mai, Thi Trang Nguyen, Hoang Anh Chu, Thi Thu Hien Vu, Thi Thu Ha Le, Quoc Hung |
author_facet | Pham, Thi Hai Yen Mai, Thi Trang Nguyen, Hoang Anh Chu, Thi Thu Hien Vu, Thi Thu Ha Le, Quoc Hung |
author_sort | Pham, Thi Hai Yen |
collection | PubMed |
description | A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode by a chronoamperometry process at 5 V and then an electrochemical reduction process was carried out to form RGOnS with restored long-range conjugated networks and better conductivity. The electrodes were characterized by SEM, EDX, and FTIR spectroscopy. The RGOnS electrode prepared at an optimal reduction potential of −1 V for 120 s exhibits a larger electrochemical active surface area, and the obtained oxidation signal of AMX is approximately ten times higher than that of the pristine graphite electrode. The analytical conditions such as the pH of electrolyte and accumulation time were optimized. The calibration curve built under the optimal conditions provided a good linear relationship in the range of AMX concentration from 0.5–80 µM with the correlation coefficient of 0.9992. The limit of detection was calculated as 0.193 µM. Satisfactory results are obtained from the detection of the AMX in different samples using the prepared electrode. |
format | Online Article Text |
id | pubmed-8099507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80995072021-05-17 Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode Pham, Thi Hai Yen Mai, Thi Trang Nguyen, Hoang Anh Chu, Thi Thu Hien Vu, Thi Thu Ha Le, Quoc Hung J Anal Methods Chem Research Article A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode by a chronoamperometry process at 5 V and then an electrochemical reduction process was carried out to form RGOnS with restored long-range conjugated networks and better conductivity. The electrodes were characterized by SEM, EDX, and FTIR spectroscopy. The RGOnS electrode prepared at an optimal reduction potential of −1 V for 120 s exhibits a larger electrochemical active surface area, and the obtained oxidation signal of AMX is approximately ten times higher than that of the pristine graphite electrode. The analytical conditions such as the pH of electrolyte and accumulation time were optimized. The calibration curve built under the optimal conditions provided a good linear relationship in the range of AMX concentration from 0.5–80 µM with the correlation coefficient of 0.9992. The limit of detection was calculated as 0.193 µM. Satisfactory results are obtained from the detection of the AMX in different samples using the prepared electrode. Hindawi 2021-04-28 /pmc/articles/PMC8099507/ /pubmed/34007510 http://dx.doi.org/10.1155/2021/8823452 Text en Copyright © 2021 Thi Hai Yen Pham et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pham, Thi Hai Yen Mai, Thi Trang Nguyen, Hoang Anh Chu, Thi Thu Hien Vu, Thi Thu Ha Le, Quoc Hung Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode |
title | Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode |
title_full | Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode |
title_fullStr | Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode |
title_full_unstemmed | Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode |
title_short | Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode |
title_sort | voltammetric determination of amoxicillin using a reduced graphite oxide nanosheet electrode |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099507/ https://www.ncbi.nlm.nih.gov/pubmed/34007510 http://dx.doi.org/10.1155/2021/8823452 |
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