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Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis
AIMS: Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099530/ https://www.ncbi.nlm.nih.gov/pubmed/33997007 http://dx.doi.org/10.1155/2021/5557309 |
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author | Aalami, Amir Hossein Abdeahad, Hossein Mesgari, Mohammad Sathyapalan, Thozhukat Sahebkar, Amirhossein |
author_facet | Aalami, Amir Hossein Abdeahad, Hossein Mesgari, Mohammad Sathyapalan, Thozhukat Sahebkar, Amirhossein |
author_sort | Aalami, Amir Hossein |
collection | PubMed |
description | AIMS: Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients' urine with bladder neoplasm. METHODS: We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10(th) October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR(+)), negative likelihood ratio (LR(−)), Q(∗) index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. RESULTS: Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR(+) of 3.34 (95% CI: 2.02–5.53), LR(−) of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q(∗) index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. CONCLUSION: This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients. |
format | Online Article Text |
id | pubmed-8099530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80995302021-05-13 Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis Aalami, Amir Hossein Abdeahad, Hossein Mesgari, Mohammad Sathyapalan, Thozhukat Sahebkar, Amirhossein Biomed Res Int Review Article AIMS: Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients' urine with bladder neoplasm. METHODS: We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10(th) October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR(+)), negative likelihood ratio (LR(−)), Q(∗) index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. RESULTS: Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR(+) of 3.34 (95% CI: 2.02–5.53), LR(−) of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q(∗) index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. CONCLUSION: This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients. Hindawi 2021-04-27 /pmc/articles/PMC8099530/ /pubmed/33997007 http://dx.doi.org/10.1155/2021/5557309 Text en Copyright © 2021 Amir Hossein Aalami et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Aalami, Amir Hossein Abdeahad, Hossein Mesgari, Mohammad Sathyapalan, Thozhukat Sahebkar, Amirhossein Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis |
title | Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis |
title_full | Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis |
title_fullStr | Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis |
title_full_unstemmed | Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis |
title_short | Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis |
title_sort | urinary angiogenin as a marker for bladder cancer: a meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099530/ https://www.ncbi.nlm.nih.gov/pubmed/33997007 http://dx.doi.org/10.1155/2021/5557309 |
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