Cargando…
Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy
OBJECTIVE: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. METHODS: The cohorts included a total of 528 patients from the Surveillance,...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Second Military Medical University
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099636/ https://www.ncbi.nlm.nih.gov/pubmed/33996481 http://dx.doi.org/10.1016/j.ajur.2020.05.005 |
_version_ | 1783688611733962752 |
---|---|
author | Liu, Mengzhu Jin, Kun Qiu, Shi Xu, Pengyong Zhang, Mingming Cai, Wufeng Zheng, Xiaonan Yang, Lu Wei, Qiang |
author_facet | Liu, Mengzhu Jin, Kun Qiu, Shi Xu, Pengyong Zhang, Mingming Cai, Wufeng Zheng, Xiaonan Yang, Lu Wei, Qiang |
author_sort | Liu, Mengzhu |
collection | PubMed |
description | OBJECTIVE: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. METHODS: The cohorts included a total of 528 patients from the Surveillance, Epidemiology and End Results (SEER) database, 354 receiving RP and 174 receiving RT. Cox proportional hazards regressions were performed to assess cancer specific mortality (CSM) and overall mortality (OM) between treatment groups. A competing risk analysis was further conducted. Subgroup analyses by age and level of prostate-specific antigen (PSA) were performed. Propensity score matching was implemented. RESULTS: Patients managed with RP had lower risks of CSM and OM compared with RT (before matching: Hazard ratio [HR]=0.24, 95% confidence interval [CI] 0.13–0.47 and HR=0.26, 95% CI 0.17–0.40, respectively; after matching: HR=0.18, 95% CI 0.04–0.82 and HR=0.28, 95% CI 0.11–0.70, accordingly). Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly (HR=0.18, 95% CI 0.06–0.57, p<0.01 and HR=0.17, 95% CI 0.06–0.54, p<0.01). CONCLUSION: Among patients with DAC, treatment with RP was associated with better survival outcomes in comparison with RT. Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP. |
format | Online Article Text |
id | pubmed-8099636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Second Military Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-80996362021-05-13 Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy Liu, Mengzhu Jin, Kun Qiu, Shi Xu, Pengyong Zhang, Mingming Cai, Wufeng Zheng, Xiaonan Yang, Lu Wei, Qiang Asian J Urol Original Article OBJECTIVE: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. METHODS: The cohorts included a total of 528 patients from the Surveillance, Epidemiology and End Results (SEER) database, 354 receiving RP and 174 receiving RT. Cox proportional hazards regressions were performed to assess cancer specific mortality (CSM) and overall mortality (OM) between treatment groups. A competing risk analysis was further conducted. Subgroup analyses by age and level of prostate-specific antigen (PSA) were performed. Propensity score matching was implemented. RESULTS: Patients managed with RP had lower risks of CSM and OM compared with RT (before matching: Hazard ratio [HR]=0.24, 95% confidence interval [CI] 0.13–0.47 and HR=0.26, 95% CI 0.17–0.40, respectively; after matching: HR=0.18, 95% CI 0.04–0.82 and HR=0.28, 95% CI 0.11–0.70, accordingly). Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly (HR=0.18, 95% CI 0.06–0.57, p<0.01 and HR=0.17, 95% CI 0.06–0.54, p<0.01). CONCLUSION: Among patients with DAC, treatment with RP was associated with better survival outcomes in comparison with RT. Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP. Second Military Medical University 2021-04 2020-05-23 /pmc/articles/PMC8099636/ /pubmed/33996481 http://dx.doi.org/10.1016/j.ajur.2020.05.005 Text en © 2021 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Liu, Mengzhu Jin, Kun Qiu, Shi Xu, Pengyong Zhang, Mingming Cai, Wufeng Zheng, Xiaonan Yang, Lu Wei, Qiang Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
title | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
title_full | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
title_fullStr | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
title_full_unstemmed | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
title_short | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
title_sort | oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099636/ https://www.ncbi.nlm.nih.gov/pubmed/33996481 http://dx.doi.org/10.1016/j.ajur.2020.05.005 |
work_keys_str_mv | AT liumengzhu oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT jinkun oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT qiushi oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT xupengyong oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT zhangmingming oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT caiwufeng oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT zhengxiaonan oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT yanglu oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy AT weiqiang oncologicaloutcomesofpatientswithductaladenocarcinomaoftheprostatereceivingradicalprostatectomyorradiotherapy |