Cargando…

ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients

Severe acute respiratory syndrome coronavirus 2, the etiologic agent of coronavirus disease 2019 (COVID-19) and the cause of the current pandemic, produces multiform manifestations throughout the body, causing indiscriminate damage to multiple organ systems, particularly the lungs, heart, brain, kid...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramos, Simone Gusmão, Rattis, Bruna Amanda da Cruz, Ottaviani, Giulia, Celes, Mara Rubia Nunes, Dias, Eliane Pedra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology. Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099789/
https://www.ncbi.nlm.nih.gov/pubmed/33964216
http://dx.doi.org/10.1016/j.ajpath.2021.04.010
_version_ 1783688646607503360
author Ramos, Simone Gusmão
Rattis, Bruna Amanda da Cruz
Ottaviani, Giulia
Celes, Mara Rubia Nunes
Dias, Eliane Pedra
author_facet Ramos, Simone Gusmão
Rattis, Bruna Amanda da Cruz
Ottaviani, Giulia
Celes, Mara Rubia Nunes
Dias, Eliane Pedra
author_sort Ramos, Simone Gusmão
collection PubMed
description Severe acute respiratory syndrome coronavirus 2, the etiologic agent of coronavirus disease 2019 (COVID-19) and the cause of the current pandemic, produces multiform manifestations throughout the body, causing indiscriminate damage to multiple organ systems, particularly the lungs, heart, brain, kidney, and vasculature. The aim of this review is to provide a new assessment of the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of angiotensin-converting enzyme 2, and consequently, deregulates the renin-angiotensin-aldosterone system, promoting important changes in the microcirculatory environment. Another goal of the article is to show how these microcirculatory changes may be responsible for the wide variety of injury mechanisms observed in different organs in this disease. The new concept of COVID-19 provides a unifying pathophysiological picture of this infection and offers fresh insights for a rational treatment strategy to combat this ongoing pandemic.
format Online
Article
Text
id pubmed-8099789
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Society for Investigative Pathology. Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-80997892021-05-06 ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients Ramos, Simone Gusmão Rattis, Bruna Amanda da Cruz Ottaviani, Giulia Celes, Mara Rubia Nunes Dias, Eliane Pedra Am J Pathol Review Severe acute respiratory syndrome coronavirus 2, the etiologic agent of coronavirus disease 2019 (COVID-19) and the cause of the current pandemic, produces multiform manifestations throughout the body, causing indiscriminate damage to multiple organ systems, particularly the lungs, heart, brain, kidney, and vasculature. The aim of this review is to provide a new assessment of the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of angiotensin-converting enzyme 2, and consequently, deregulates the renin-angiotensin-aldosterone system, promoting important changes in the microcirculatory environment. Another goal of the article is to show how these microcirculatory changes may be responsible for the wide variety of injury mechanisms observed in different organs in this disease. The new concept of COVID-19 provides a unifying pathophysiological picture of this infection and offers fresh insights for a rational treatment strategy to combat this ongoing pandemic. American Society for Investigative Pathology. Published by Elsevier Inc. 2021-07 2021-05-06 /pmc/articles/PMC8099789/ /pubmed/33964216 http://dx.doi.org/10.1016/j.ajpath.2021.04.010 Text en © 2021 American Society for Investigative Pathology. Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Ramos, Simone Gusmão
Rattis, Bruna Amanda da Cruz
Ottaviani, Giulia
Celes, Mara Rubia Nunes
Dias, Eliane Pedra
ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
title ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
title_full ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
title_fullStr ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
title_full_unstemmed ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
title_short ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients
title_sort ace2 down-regulation may act as a transient molecular disease causing raas dysregulation and tissue damage in the microcirculatory environment among covid-19 patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099789/
https://www.ncbi.nlm.nih.gov/pubmed/33964216
http://dx.doi.org/10.1016/j.ajpath.2021.04.010
work_keys_str_mv AT ramossimonegusmao ace2downregulationmayactasatransientmoleculardiseasecausingraasdysregulationandtissuedamageinthemicrocirculatoryenvironmentamongcovid19patients
AT rattisbrunaamandadacruz ace2downregulationmayactasatransientmoleculardiseasecausingraasdysregulationandtissuedamageinthemicrocirculatoryenvironmentamongcovid19patients
AT ottavianigiulia ace2downregulationmayactasatransientmoleculardiseasecausingraasdysregulationandtissuedamageinthemicrocirculatoryenvironmentamongcovid19patients
AT celesmararubianunes ace2downregulationmayactasatransientmoleculardiseasecausingraasdysregulationandtissuedamageinthemicrocirculatoryenvironmentamongcovid19patients
AT diaselianepedra ace2downregulationmayactasatransientmoleculardiseasecausingraasdysregulationandtissuedamageinthemicrocirculatoryenvironmentamongcovid19patients