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Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with head...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099815/ https://www.ncbi.nlm.nih.gov/pubmed/32918169 http://dx.doi.org/10.1007/s00428-020-02923-4 |
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author | Quah, Boon Leong Donofrio, Carmine Antonio La Rosa, Stefano Brouland, Jean-Philippe Cossu, Giulia Djoukhadar, Ibrahim Mayers, Helen Shenjere, Patrick Pereira, Marta Pathmanaban, Omar N. Murtaza, Muhammed O. Gattamaneni, Rao Roncaroli, Federico Karabatsou, Konstantina |
author_facet | Quah, Boon Leong Donofrio, Carmine Antonio La Rosa, Stefano Brouland, Jean-Philippe Cossu, Giulia Djoukhadar, Ibrahim Mayers, Helen Shenjere, Patrick Pereira, Marta Pathmanaban, Omar N. Murtaza, Muhammed O. Gattamaneni, Rao Roncaroli, Federico Karabatsou, Konstantina |
author_sort | Quah, Boon Leong |
collection | PubMed |
description | Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour. |
format | Online Article Text |
id | pubmed-8099815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-80998152021-05-11 Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm Quah, Boon Leong Donofrio, Carmine Antonio La Rosa, Stefano Brouland, Jean-Philippe Cossu, Giulia Djoukhadar, Ibrahim Mayers, Helen Shenjere, Patrick Pereira, Marta Pathmanaban, Omar N. Murtaza, Muhammed O. Gattamaneni, Rao Roncaroli, Federico Karabatsou, Konstantina Virchows Arch Original Article Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour. Springer Berlin Heidelberg 2020-09-12 2021 /pmc/articles/PMC8099815/ /pubmed/32918169 http://dx.doi.org/10.1007/s00428-020-02923-4 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Quah, Boon Leong Donofrio, Carmine Antonio La Rosa, Stefano Brouland, Jean-Philippe Cossu, Giulia Djoukhadar, Ibrahim Mayers, Helen Shenjere, Patrick Pereira, Marta Pathmanaban, Omar N. Murtaza, Muhammed O. Gattamaneni, Rao Roncaroli, Federico Karabatsou, Konstantina Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
title | Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
title_full | Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
title_fullStr | Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
title_full_unstemmed | Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
title_short | Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
title_sort | primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099815/ https://www.ncbi.nlm.nih.gov/pubmed/32918169 http://dx.doi.org/10.1007/s00428-020-02923-4 |
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