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Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm

Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with head...

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Autores principales: Quah, Boon Leong, Donofrio, Carmine Antonio, La Rosa, Stefano, Brouland, Jean-Philippe, Cossu, Giulia, Djoukhadar, Ibrahim, Mayers, Helen, Shenjere, Patrick, Pereira, Marta, Pathmanaban, Omar N., Murtaza, Muhammed O., Gattamaneni, Rao, Roncaroli, Federico, Karabatsou, Konstantina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099815/
https://www.ncbi.nlm.nih.gov/pubmed/32918169
http://dx.doi.org/10.1007/s00428-020-02923-4
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author Quah, Boon Leong
Donofrio, Carmine Antonio
La Rosa, Stefano
Brouland, Jean-Philippe
Cossu, Giulia
Djoukhadar, Ibrahim
Mayers, Helen
Shenjere, Patrick
Pereira, Marta
Pathmanaban, Omar N.
Murtaza, Muhammed O.
Gattamaneni, Rao
Roncaroli, Federico
Karabatsou, Konstantina
author_facet Quah, Boon Leong
Donofrio, Carmine Antonio
La Rosa, Stefano
Brouland, Jean-Philippe
Cossu, Giulia
Djoukhadar, Ibrahim
Mayers, Helen
Shenjere, Patrick
Pereira, Marta
Pathmanaban, Omar N.
Murtaza, Muhammed O.
Gattamaneni, Rao
Roncaroli, Federico
Karabatsou, Konstantina
author_sort Quah, Boon Leong
collection PubMed
description Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour.
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spelling pubmed-80998152021-05-11 Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm Quah, Boon Leong Donofrio, Carmine Antonio La Rosa, Stefano Brouland, Jean-Philippe Cossu, Giulia Djoukhadar, Ibrahim Mayers, Helen Shenjere, Patrick Pereira, Marta Pathmanaban, Omar N. Murtaza, Muhammed O. Gattamaneni, Rao Roncaroli, Federico Karabatsou, Konstantina Virchows Arch Original Article Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour. Springer Berlin Heidelberg 2020-09-12 2021 /pmc/articles/PMC8099815/ /pubmed/32918169 http://dx.doi.org/10.1007/s00428-020-02923-4 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Quah, Boon Leong
Donofrio, Carmine Antonio
La Rosa, Stefano
Brouland, Jean-Philippe
Cossu, Giulia
Djoukhadar, Ibrahim
Mayers, Helen
Shenjere, Patrick
Pereira, Marta
Pathmanaban, Omar N.
Murtaza, Muhammed O.
Gattamaneni, Rao
Roncaroli, Federico
Karabatsou, Konstantina
Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
title Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
title_full Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
title_fullStr Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
title_full_unstemmed Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
title_short Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
title_sort primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099815/
https://www.ncbi.nlm.nih.gov/pubmed/32918169
http://dx.doi.org/10.1007/s00428-020-02923-4
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