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Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB

PURPOSE: Moderate-to-high correlations have been reported between the [(11)C]PiB PET-derived relative tracer delivery rate R(1) and relative CBF as measured using [(15)O]H(2)O PET, supporting its use as a proxy of relative CBF. As longitudinal PET studies become more common for measuring treatment e...

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Autores principales: Heeman, Fiona, Hendriks, Janine, Lopes Alves, Isadora, Tolboom, Nelleke, van Berckel, Bart N. M., Yaqub, Maqsood, Lammertsma, Adriaan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099850/
https://www.ncbi.nlm.nih.gov/pubmed/33884565
http://dx.doi.org/10.1007/s11307-021-01606-z
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author Heeman, Fiona
Hendriks, Janine
Lopes Alves, Isadora
Tolboom, Nelleke
van Berckel, Bart N. M.
Yaqub, Maqsood
Lammertsma, Adriaan A.
author_facet Heeman, Fiona
Hendriks, Janine
Lopes Alves, Isadora
Tolboom, Nelleke
van Berckel, Bart N. M.
Yaqub, Maqsood
Lammertsma, Adriaan A.
author_sort Heeman, Fiona
collection PubMed
description PURPOSE: Moderate-to-high correlations have been reported between the [(11)C]PiB PET-derived relative tracer delivery rate R(1) and relative CBF as measured using [(15)O]H(2)O PET, supporting its use as a proxy of relative CBF. As longitudinal PET studies become more common for measuring treatment efficacy or disease progression, it is important to know the intrinsic variability of R(1). The purpose of the present study was to determine this through a retrospective data analysis. PROCEDURES: Test-retest data belonging to twelve participants, who underwent two 90 min [(11)C]PiB PET scans, were retrospectively included. The voxel-based implementation of the two-step simplified reference tissue model with cerebellar grey matter as reference tissue was used to compute R(1) images. Next, test-retest variability was calculated, and test and retest R(1) measures were compared using linear mixed effect models and a Bland-Altman analysis. RESULTS: Test-retest variability was low across regions (max. 5.8 %), and test and retest measures showed high, significant correlations (R(2)=0.92, slope=0.98) and a negligible bias (0.69±3.07 %). CONCLUSIONS: In conclusion, the high precision of [(11)C]PiB R(1) suggests suitable applicability for cross-sectional and longitudinal studies.
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spelling pubmed-80998502021-05-11 Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB Heeman, Fiona Hendriks, Janine Lopes Alves, Isadora Tolboom, Nelleke van Berckel, Bart N. M. Yaqub, Maqsood Lammertsma, Adriaan A. Mol Imaging Biol Brief Article PURPOSE: Moderate-to-high correlations have been reported between the [(11)C]PiB PET-derived relative tracer delivery rate R(1) and relative CBF as measured using [(15)O]H(2)O PET, supporting its use as a proxy of relative CBF. As longitudinal PET studies become more common for measuring treatment efficacy or disease progression, it is important to know the intrinsic variability of R(1). The purpose of the present study was to determine this through a retrospective data analysis. PROCEDURES: Test-retest data belonging to twelve participants, who underwent two 90 min [(11)C]PiB PET scans, were retrospectively included. The voxel-based implementation of the two-step simplified reference tissue model with cerebellar grey matter as reference tissue was used to compute R(1) images. Next, test-retest variability was calculated, and test and retest R(1) measures were compared using linear mixed effect models and a Bland-Altman analysis. RESULTS: Test-retest variability was low across regions (max. 5.8 %), and test and retest measures showed high, significant correlations (R(2)=0.92, slope=0.98) and a negligible bias (0.69±3.07 %). CONCLUSIONS: In conclusion, the high precision of [(11)C]PiB R(1) suggests suitable applicability for cross-sectional and longitudinal studies. Springer International Publishing 2021-04-21 2021 /pmc/articles/PMC8099850/ /pubmed/33884565 http://dx.doi.org/10.1007/s11307-021-01606-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Article
Heeman, Fiona
Hendriks, Janine
Lopes Alves, Isadora
Tolboom, Nelleke
van Berckel, Bart N. M.
Yaqub, Maqsood
Lammertsma, Adriaan A.
Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB
title Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB
title_full Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB
title_fullStr Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB
title_full_unstemmed Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB
title_short Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [(11)C]PiB
title_sort test-retest variability of relative tracer delivery rate as measured by [(11)c]pib
topic Brief Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099850/
https://www.ncbi.nlm.nih.gov/pubmed/33884565
http://dx.doi.org/10.1007/s11307-021-01606-z
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