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The ratio of T790M to EGFR-activating mutation predicts response of osimertinib in 1st or 2nd generation EGFR-TKI-refractory NSCLC

The most frequent mechanism of resistance after 1st/2nd-generation (G) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) is secondary point mutation Thr790Met (T790M) in EGFR. Afatinib followed by osimertinib (Afa group) may provide better outcomes for T790M-positive non-smal...

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Detalles Bibliográficos
Autores principales:	Tamiya, Motohiro, Tamiya, Akihiro, Okamoto, Norio, Taniguchi, Yoshihiko, Nishino, Kazumi, Atagi, Shinji, Hirashima, Tomonori, Imamura, Fumio, Kumagai, Toru, Suzuki, Hidekazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099906/ https://www.ncbi.nlm.nih.gov/pubmed/33953280 http://dx.doi.org/10.1038/s41598-021-89006-9

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