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IL-4Rα signaling by CD8α(+) dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8(+) T cell responses

Persistent high levels of proinflammatory and Th1 responses contribute to cerebral malaria (CM). Suppression of inflammatory responses and promotion of Th2 responses prevent pathogenesis. IL-4 commonly promotes Th2 responses and inhibits inflammatory and Th1 responses. Therefore, IL-4 is widely cons...

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Detalles Bibliográficos
Autores principales:	Wu, Xianzhu, Brombacher, Frank, Chroneos, Zissis C., Norbury, Christopher C., Gowda, D. Channe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Accelerated Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100064/ https://www.ncbi.nlm.nih.gov/pubmed/33798555 http://dx.doi.org/10.1016/j.jbc.2021.100615

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