Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms

Receptors and their ligands are important therapeutic targets for about one third of marketed drugs. Here, we describe an epitope-guided approach for selection of antibodies that modulate cellular signaling of targeted receptors. We chose CXC chemokine receptor 2 (CXCR2) in the G-protein coupled rec...

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Detalles Bibliográficos
Autores principales: Shi, Xiaojie, Wan, Yue, Wang, Nan, Xiang, Jiangchao, Wang, Tao, Yang, Xiaofeng, Wang, Ju, Dong, Xuxue, Dong, Liang, Yan, Lei, Li, Yu, Liu, Lili, Hou, Shinchen, Zhong, Zhenwei, Wilson, Ian A., Yang, Bei, Yang, Guang, Lerner, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100106/
https://www.ncbi.nlm.nih.gov/pubmed/33953162
http://dx.doi.org/10.1038/s41467-021-22810-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100106/
https://www.ncbi.nlm.nih.gov/pubmed/33953162
http://dx.doi.org/10.1038/s41467-021-22810-z

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