Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel

Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes severe heart arrhythmias due to sinoatrial node dysfunction and a debilitating gastrointestinal motility disorder, collectively termed the Chr...

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Detalles Bibliográficos
Autores principales: Liu, Donghai, Song, Andrew Taehun, Qi, Xiaoyan, van Vliet, Patrick Piet, Xiao, Jiening, Xiong, Feng, Andelfinger, Gregor, Nattel, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100125/
https://www.ncbi.nlm.nih.gov/pubmed/33953173
http://dx.doi.org/10.1038/s41467-021-22737-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100125/
https://www.ncbi.nlm.nih.gov/pubmed/33953173
http://dx.doi.org/10.1038/s41467-021-22737-5

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