Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies

The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis. Here, we present the cryo-EM structure of ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3...

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Detalles Bibliográficos
Autores principales: Zhang, Hanzhi, Huang, Ching-Shin, Yu, Xinchao, Lee, Jonas, Vaish, Amit, Chen, Qing, Zhou, Mingyue, Wang, Zhulun, Min, Xiaoshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100176/
https://www.ncbi.nlm.nih.gov/pubmed/33953337
http://dx.doi.org/10.1038/s42003-021-02039-8

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