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Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques. Experimental investigations have been critical in advancing our understanding of the control mechanisms that in...

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Autores principales: Cheng, Leo K., Nagahawatte, Nipuni D., Avci, Recep, Du, Peng, Liu, Zhongming, Paskaranandavadivel, Niranchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100207/
https://www.ncbi.nlm.nih.gov/pubmed/33967679
http://dx.doi.org/10.3389/fnins.2021.645472
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author Cheng, Leo K.
Nagahawatte, Nipuni D.
Avci, Recep
Du, Peng
Liu, Zhongming
Paskaranandavadivel, Niranchan
author_facet Cheng, Leo K.
Nagahawatte, Nipuni D.
Avci, Recep
Du, Peng
Liu, Zhongming
Paskaranandavadivel, Niranchan
author_sort Cheng, Leo K.
collection PubMed
description Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques. Experimental investigations have been critical in advancing our understanding of the control mechanisms that innervate gut function. In this review, we will discuss the use of pacing to modulate the rhythmic slow wave conduction patterns generated by interstitial cells of Cajal in the gastric musculature. In addition, the use of gastric high-frequency stimulation methods that target nerves in the stomach to either inhibit or enhance stomach function will be discussed. Pacing and stimulation protocols to modulate gastric activity, effective parameters and limitations in the existing studies are summarized. Mathematical models are useful to understand complex and dynamic systems. A review of existing mathematical models and techniques that aim to help refine pacing and stimulation protocols are provided. Finally, some future directions and challenges that should be investigated are discussed.
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spelling pubmed-81002072021-05-07 Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches Cheng, Leo K. Nagahawatte, Nipuni D. Avci, Recep Du, Peng Liu, Zhongming Paskaranandavadivel, Niranchan Front Neurosci Neuroscience Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques. Experimental investigations have been critical in advancing our understanding of the control mechanisms that innervate gut function. In this review, we will discuss the use of pacing to modulate the rhythmic slow wave conduction patterns generated by interstitial cells of Cajal in the gastric musculature. In addition, the use of gastric high-frequency stimulation methods that target nerves in the stomach to either inhibit or enhance stomach function will be discussed. Pacing and stimulation protocols to modulate gastric activity, effective parameters and limitations in the existing studies are summarized. Mathematical models are useful to understand complex and dynamic systems. A review of existing mathematical models and techniques that aim to help refine pacing and stimulation protocols are provided. Finally, some future directions and challenges that should be investigated are discussed. Frontiers Media S.A. 2021-04-22 /pmc/articles/PMC8100207/ /pubmed/33967679 http://dx.doi.org/10.3389/fnins.2021.645472 Text en Copyright © 2021 Cheng, Nagahawatte, Avci, Du, Liu and Paskaranandavadivel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cheng, Leo K.
Nagahawatte, Nipuni D.
Avci, Recep
Du, Peng
Liu, Zhongming
Paskaranandavadivel, Niranchan
Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches
title Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches
title_full Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches
title_fullStr Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches
title_full_unstemmed Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches
title_short Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches
title_sort strategies to refine gastric stimulation and pacing protocols: experimental and modeling approaches
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100207/
https://www.ncbi.nlm.nih.gov/pubmed/33967679
http://dx.doi.org/10.3389/fnins.2021.645472
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