Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse

Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal...

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Detalles Bibliográficos
Autores principales: Ibi, Kanata, Chiba, Shiori, Koyama, Naomi, Hashimoto, Kazuto, Nejishima, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100254/
https://www.ncbi.nlm.nih.gov/pubmed/33976470
http://dx.doi.org/10.1293/tox.2020-0083
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author Ibi, Kanata
Chiba, Shiori
Koyama, Naomi
Hashimoto, Kazuto
Nejishima, Hiroaki
author_facet Ibi, Kanata
Chiba, Shiori
Koyama, Naomi
Hashimoto, Kazuto
Nejishima, Hiroaki
author_sort Ibi, Kanata
collection PubMed
description Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal muscle (scalenus muscle). Histological examination showed that the tumor consisted of atypical polygonal cells, a small osteoid clump, and bone tissue. Mitotic figures were observed. Serial sections showed that neoplastic cells lacked clear invasive proliferation to adjacent normal skeletal muscle and continuity with normal bone tissue. Immunohistochemical analysis showed that the neoplastic cells were positive for osteocalcin, osterix, vimentin, and S-100. Based on these results, the tumor was diagnosed as extraskeletal osteosarcoma in the neck skeletal muscle.
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spelling pubmed-81002542021-05-10 Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse Ibi, Kanata Chiba, Shiori Koyama, Naomi Hashimoto, Kazuto Nejishima, Hiroaki J Toxicol Pathol Case Report Extraskeletal osteosarcoma is extremely rare in humans and animals, especially in rodents. This is the first case report on spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse (36 weeks, dead). Necropsy revealed a solid white mass located in the neck skeletal muscle (scalenus muscle). Histological examination showed that the tumor consisted of atypical polygonal cells, a small osteoid clump, and bone tissue. Mitotic figures were observed. Serial sections showed that neoplastic cells lacked clear invasive proliferation to adjacent normal skeletal muscle and continuity with normal bone tissue. Immunohistochemical analysis showed that the neoplastic cells were positive for osteocalcin, osterix, vimentin, and S-100. Based on these results, the tumor was diagnosed as extraskeletal osteosarcoma in the neck skeletal muscle. Japanese Society of Toxicologic Pathology 2021-01-18 2021-04 /pmc/articles/PMC8100254/ /pubmed/33976470 http://dx.doi.org/10.1293/tox.2020-0083 Text en ©2021 The Japanese Society of Toxicologic Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.
spellingShingle Case Report
Ibi, Kanata
Chiba, Shiori
Koyama, Naomi
Hashimoto, Kazuto
Nejishima, Hiroaki
Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
title Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
title_full Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
title_fullStr Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
title_full_unstemmed Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
title_short Spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a Crlj:CD1 (ICR) mouse
title_sort spontaneous extraskeletal osteosarcoma in the neck skeletal muscle of a crlj:cd1 (icr) mouse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100254/
https://www.ncbi.nlm.nih.gov/pubmed/33976470
http://dx.doi.org/10.1293/tox.2020-0083
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