Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

Osteoporosis and other manifestations of bone disease are frequent in patients with systemic mastocytosis (SM) in association with the presence of mast cell infiltrates in bone marrow, although the mechanisms behind bone disease remain poorly understood. We find that extracellular vesicles (EVs) rel...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Do-Kyun, Bandara, Geethani, Cho, Young-Eun, Komarow, Hirsh D., Donahue, Danielle R., Karim, Baktiar, Baek, Moon-Chang, Kim, Ho Min, Metcalfe, Dean D., Olivera, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100305/
https://www.ncbi.nlm.nih.gov/pubmed/33953168
http://dx.doi.org/10.1038/s41467-021-22754-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100305/
https://www.ncbi.nlm.nih.gov/pubmed/33953168
http://dx.doi.org/10.1038/s41467-021-22754-4

Ejemplares similares