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Emergence of Neuronal Synchronisation in Coupled Areas

One of the most fundamental questions in the field of neuroscience is the emergence of synchronous behaviour in the brain, such as phase, anti-phase, and shift-phase synchronisation. In this work, we investigate how the connectivity between brain areas can influence the phase angle and the neuronal...

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Autores principales: Protachevicz, Paulo R., Hansen, Matheus, Iarosz, Kelly C., Caldas, Iberê L., Batista, Antonio M., Kurths, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100315/
https://www.ncbi.nlm.nih.gov/pubmed/33967729
http://dx.doi.org/10.3389/fncom.2021.663408
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author Protachevicz, Paulo R.
Hansen, Matheus
Iarosz, Kelly C.
Caldas, Iberê L.
Batista, Antonio M.
Kurths, Jürgen
author_facet Protachevicz, Paulo R.
Hansen, Matheus
Iarosz, Kelly C.
Caldas, Iberê L.
Batista, Antonio M.
Kurths, Jürgen
author_sort Protachevicz, Paulo R.
collection PubMed
description One of the most fundamental questions in the field of neuroscience is the emergence of synchronous behaviour in the brain, such as phase, anti-phase, and shift-phase synchronisation. In this work, we investigate how the connectivity between brain areas can influence the phase angle and the neuronal synchronisation. To do this, we consider brain areas connected by means of excitatory and inhibitory synapses, in which the neuron dynamics is given by the adaptive exponential integrate-and-fire model. Our simulations suggest that excitatory and inhibitory connections from one area to another play a crucial role in the emergence of these types of synchronisation. Thus, in the case of unidirectional interaction, we observe that the phase angles of the neurons in the receiver area depend on the excitatory and inhibitory synapses which arrive from the sender area. Moreover, when the neurons in the sender area are synchronised, the phase angle variability of the receiver area can be reduced for some conductance values between the areas. For bidirectional interactions, we find that phase and anti-phase synchronisation can emerge due to excitatory and inhibitory connections. We also verify, for a strong inhibitory-to-excitatory interaction, the existence of silent neuronal activities, namely a large number of excitatory neurons that remain in silence for a long time.
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spelling pubmed-81003152021-05-07 Emergence of Neuronal Synchronisation in Coupled Areas Protachevicz, Paulo R. Hansen, Matheus Iarosz, Kelly C. Caldas, Iberê L. Batista, Antonio M. Kurths, Jürgen Front Comput Neurosci Neuroscience One of the most fundamental questions in the field of neuroscience is the emergence of synchronous behaviour in the brain, such as phase, anti-phase, and shift-phase synchronisation. In this work, we investigate how the connectivity between brain areas can influence the phase angle and the neuronal synchronisation. To do this, we consider brain areas connected by means of excitatory and inhibitory synapses, in which the neuron dynamics is given by the adaptive exponential integrate-and-fire model. Our simulations suggest that excitatory and inhibitory connections from one area to another play a crucial role in the emergence of these types of synchronisation. Thus, in the case of unidirectional interaction, we observe that the phase angles of the neurons in the receiver area depend on the excitatory and inhibitory synapses which arrive from the sender area. Moreover, when the neurons in the sender area are synchronised, the phase angle variability of the receiver area can be reduced for some conductance values between the areas. For bidirectional interactions, we find that phase and anti-phase synchronisation can emerge due to excitatory and inhibitory connections. We also verify, for a strong inhibitory-to-excitatory interaction, the existence of silent neuronal activities, namely a large number of excitatory neurons that remain in silence for a long time. Frontiers Media S.A. 2021-04-22 /pmc/articles/PMC8100315/ /pubmed/33967729 http://dx.doi.org/10.3389/fncom.2021.663408 Text en Copyright © 2021 Protachevicz, Hansen, Iarosz, Caldas, Batista and Kurths. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Protachevicz, Paulo R.
Hansen, Matheus
Iarosz, Kelly C.
Caldas, Iberê L.
Batista, Antonio M.
Kurths, Jürgen
Emergence of Neuronal Synchronisation in Coupled Areas
title Emergence of Neuronal Synchronisation in Coupled Areas
title_full Emergence of Neuronal Synchronisation in Coupled Areas
title_fullStr Emergence of Neuronal Synchronisation in Coupled Areas
title_full_unstemmed Emergence of Neuronal Synchronisation in Coupled Areas
title_short Emergence of Neuronal Synchronisation in Coupled Areas
title_sort emergence of neuronal synchronisation in coupled areas
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100315/
https://www.ncbi.nlm.nih.gov/pubmed/33967729
http://dx.doi.org/10.3389/fncom.2021.663408
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