Cargando…

Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies

Parkinson’s disease (PD) is a common neurodegenerative disease featured by progressive degeneration of nigrostriatal dopaminergic neurons (DA) accompanied with motor function impairment. Accumulating evidence has demonstrated that natural compounds from herbs have potent anti-PD efficacy in PD model...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Cheng-Fu, Jiang, Li, Zhang, Xiao-Wen, Iyaswamy, Ashok, Li, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100515/
https://www.ncbi.nlm.nih.gov/pubmed/33967780
http://dx.doi.org/10.3389/fphar.2021.644219
_version_ 1783688807627882496
author Su, Cheng-Fu
Jiang, Li
Zhang, Xiao-Wen
Iyaswamy, Ashok
Li, Min
author_facet Su, Cheng-Fu
Jiang, Li
Zhang, Xiao-Wen
Iyaswamy, Ashok
Li, Min
author_sort Su, Cheng-Fu
collection PubMed
description Parkinson’s disease (PD) is a common neurodegenerative disease featured by progressive degeneration of nigrostriatal dopaminergic neurons (DA) accompanied with motor function impairment. Accumulating evidence has demonstrated that natural compounds from herbs have potent anti-PD efficacy in PD models. Among those compounds, resveratrol, a polyphenol found in many common plants and fruits, is more effective against PD. Resveratrol has displayed a potent neuroprotective efficacy in several PD animal models. However, there is still no systematic analysis of the quality of methodological design of these studies, nor of their results. In this review, we retrieved and analyzed 18 studies describing the therapeutic effect of resveratrol on PD animal models. There are 5 main kinds of PD rodent models involved in the 18 articles, including chemical-induced (MPTP, rotenone, 6-OHDA, paraquat, and maneb) and transgenic PD models. The neuroprotective mechanisms of resveratrol were mainly concentrated on the antioxidation, anti-inflammation, ameliorating mitochondrial dysfunction, and motor function. We discussed the disadvantages of different PD animal models, and we used meta-analysis approach to evaluate the results of the selected studies and used SYRCLE’s risk of bias tool to evaluate the methodological quality. Our analytical approach minimized the bias of different studies. We have also summarized the pharmacological mechanisms of resveratrol on PD models as reported by the researchers. The results of this study support the notion that resveratrol has significant neuroprotective effects on different PD models quantified using qualitative and quantitative methods. The collective information in our review can guide researchers to further plan their future experiments without any hassle regarding preclinical and clinical studies. In addition, this collective assessment of animal studies can provide a qualitative analysis of different PD animal models, either to guide further testing of these models or to avoid unnecessary duplication in their future research.
format Online
Article
Text
id pubmed-8100515
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81005152021-05-07 Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies Su, Cheng-Fu Jiang, Li Zhang, Xiao-Wen Iyaswamy, Ashok Li, Min Front Pharmacol Pharmacology Parkinson’s disease (PD) is a common neurodegenerative disease featured by progressive degeneration of nigrostriatal dopaminergic neurons (DA) accompanied with motor function impairment. Accumulating evidence has demonstrated that natural compounds from herbs have potent anti-PD efficacy in PD models. Among those compounds, resveratrol, a polyphenol found in many common plants and fruits, is more effective against PD. Resveratrol has displayed a potent neuroprotective efficacy in several PD animal models. However, there is still no systematic analysis of the quality of methodological design of these studies, nor of their results. In this review, we retrieved and analyzed 18 studies describing the therapeutic effect of resveratrol on PD animal models. There are 5 main kinds of PD rodent models involved in the 18 articles, including chemical-induced (MPTP, rotenone, 6-OHDA, paraquat, and maneb) and transgenic PD models. The neuroprotective mechanisms of resveratrol were mainly concentrated on the antioxidation, anti-inflammation, ameliorating mitochondrial dysfunction, and motor function. We discussed the disadvantages of different PD animal models, and we used meta-analysis approach to evaluate the results of the selected studies and used SYRCLE’s risk of bias tool to evaluate the methodological quality. Our analytical approach minimized the bias of different studies. We have also summarized the pharmacological mechanisms of resveratrol on PD models as reported by the researchers. The results of this study support the notion that resveratrol has significant neuroprotective effects on different PD models quantified using qualitative and quantitative methods. The collective information in our review can guide researchers to further plan their future experiments without any hassle regarding preclinical and clinical studies. In addition, this collective assessment of animal studies can provide a qualitative analysis of different PD animal models, either to guide further testing of these models or to avoid unnecessary duplication in their future research. Frontiers Media S.A. 2021-04-22 /pmc/articles/PMC8100515/ /pubmed/33967780 http://dx.doi.org/10.3389/fphar.2021.644219 Text en Copyright © 2021 Su, Jiang, Zhang, Iyaswamy and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Su, Cheng-Fu
Jiang, Li
Zhang, Xiao-Wen
Iyaswamy, Ashok
Li, Min
Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
title Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
title_full Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
title_fullStr Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
title_full_unstemmed Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
title_short Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
title_sort resveratrol in rodent models of parkinson’s disease: a systematic review of experimental studies
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100515/
https://www.ncbi.nlm.nih.gov/pubmed/33967780
http://dx.doi.org/10.3389/fphar.2021.644219
work_keys_str_mv AT suchengfu resveratrolinrodentmodelsofparkinsonsdiseaseasystematicreviewofexperimentalstudies
AT jiangli resveratrolinrodentmodelsofparkinsonsdiseaseasystematicreviewofexperimentalstudies
AT zhangxiaowen resveratrolinrodentmodelsofparkinsonsdiseaseasystematicreviewofexperimentalstudies
AT iyaswamyashok resveratrolinrodentmodelsofparkinsonsdiseaseasystematicreviewofexperimentalstudies
AT limin resveratrolinrodentmodelsofparkinsonsdiseaseasystematicreviewofexperimentalstudies