Cargando…

Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors

OBJECTIVE: The aim of this study was to determine the rate of coronavirus disease‐19 (COVID‐19) among patients with cancer treated with immune checkpoint inhibitors (ICIs). MATERIALS AND METHODS: This was a retrospective study of 1,545 patients with cancer treated with ICIs between July 1, 2019, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Klebanov, Nikolai, Pahalyants, Vartan, Murphy, William S., Theodosakis, Nicholas, Zubiri, Leyre, Klevens, R. Monina, Kwatra, Shawn G., Lilly, Evelyn, Reynolds, Kerry L., Semenov, Yevgeniy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100539/
https://www.ncbi.nlm.nih.gov/pubmed/33783099
http://dx.doi.org/10.1002/onco.13768
_version_ 1783688812898025472
author Klebanov, Nikolai
Pahalyants, Vartan
Murphy, William S.
Theodosakis, Nicholas
Zubiri, Leyre
Klevens, R. Monina
Kwatra, Shawn G.
Lilly, Evelyn
Reynolds, Kerry L.
Semenov, Yevgeniy R.
author_facet Klebanov, Nikolai
Pahalyants, Vartan
Murphy, William S.
Theodosakis, Nicholas
Zubiri, Leyre
Klevens, R. Monina
Kwatra, Shawn G.
Lilly, Evelyn
Reynolds, Kerry L.
Semenov, Yevgeniy R.
author_sort Klebanov, Nikolai
collection PubMed
description OBJECTIVE: The aim of this study was to determine the rate of coronavirus disease‐19 (COVID‐19) among patients with cancer treated with immune checkpoint inhibitors (ICIs). MATERIALS AND METHODS: This was a retrospective study of 1,545 patients with cancer treated with ICIs between July 1, 2019, and February 29, 2020, and 20,418 age‐, sex‐, and cancer category‐matched controls in a large referral hospital system. Confirmed COVID‐19 case and mortality data were obtained with Massachusetts Department of Public Health from March 1 through June 19, 2020. RESULTS: The mean age was 66.6 years, and 41.9% were female. There were 22 (1.4%) and 213 (1.0%) COVID‐19 cases in the ICI and control groups, respectively. When adjusting for demographics, medical comorbidities, and local infection rates, ICIs did not increase COVID‐19 susceptibility. CONCLUSION: ICIs did not increase the rate of COVID‐19. This information may assist patients and their oncologists in decision‐making surrounding cancer treatment during this pandemic.
format Online
Article
Text
id pubmed-8100539
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-81005392021-05-10 Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors Klebanov, Nikolai Pahalyants, Vartan Murphy, William S. Theodosakis, Nicholas Zubiri, Leyre Klevens, R. Monina Kwatra, Shawn G. Lilly, Evelyn Reynolds, Kerry L. Semenov, Yevgeniy R. Oncologist Brief Communications OBJECTIVE: The aim of this study was to determine the rate of coronavirus disease‐19 (COVID‐19) among patients with cancer treated with immune checkpoint inhibitors (ICIs). MATERIALS AND METHODS: This was a retrospective study of 1,545 patients with cancer treated with ICIs between July 1, 2019, and February 29, 2020, and 20,418 age‐, sex‐, and cancer category‐matched controls in a large referral hospital system. Confirmed COVID‐19 case and mortality data were obtained with Massachusetts Department of Public Health from March 1 through June 19, 2020. RESULTS: The mean age was 66.6 years, and 41.9% were female. There were 22 (1.4%) and 213 (1.0%) COVID‐19 cases in the ICI and control groups, respectively. When adjusting for demographics, medical comorbidities, and local infection rates, ICIs did not increase COVID‐19 susceptibility. CONCLUSION: ICIs did not increase the rate of COVID‐19. This information may assist patients and their oncologists in decision‐making surrounding cancer treatment during this pandemic. John Wiley & Sons, Inc. 2021-04-17 2021-05 /pmc/articles/PMC8100539/ /pubmed/33783099 http://dx.doi.org/10.1002/onco.13768 Text en © 2021 AlphaMed Press
spellingShingle Brief Communications
Klebanov, Nikolai
Pahalyants, Vartan
Murphy, William S.
Theodosakis, Nicholas
Zubiri, Leyre
Klevens, R. Monina
Kwatra, Shawn G.
Lilly, Evelyn
Reynolds, Kerry L.
Semenov, Yevgeniy R.
Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors
title Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors
title_full Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors
title_fullStr Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors
title_full_unstemmed Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors
title_short Risk of COVID‐19 in Patients with Cancer Receiving Immune Checkpoint Inhibitors
title_sort risk of covid‐19 in patients with cancer receiving immune checkpoint inhibitors
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100539/
https://www.ncbi.nlm.nih.gov/pubmed/33783099
http://dx.doi.org/10.1002/onco.13768
work_keys_str_mv AT klebanovnikolai riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT pahalyantsvartan riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT murphywilliams riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT theodosakisnicholas riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT zubirileyre riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT klevensrmonina riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT kwatrashawng riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT lillyevelyn riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT reynoldskerryl riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors
AT semenovyevgeniyr riskofcovid19inpatientswithcancerreceivingimmunecheckpointinhibitors