Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers

The incidence of urological cancer has been gradually increasing in the last few decades. However, current diagnostic tools and treatment strategies continue to have limitations. Substantial evidence shows that long noncoding RNAs (lncRNAs) play essential roles in carcinogenesis and the progression,...

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Detalles Bibliográficos
Autores principales: Yang, Zitong, Li, Qinchen, Zheng, Xiangyi, Xie, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100577/
https://www.ncbi.nlm.nih.gov/pubmed/33968736
http://dx.doi.org/10.3389/fonc.2021.638721
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author Yang, Zitong
Li, Qinchen
Zheng, Xiangyi
Xie, Liping
author_facet Yang, Zitong
Li, Qinchen
Zheng, Xiangyi
Xie, Liping
author_sort Yang, Zitong
collection PubMed
description The incidence of urological cancer has been gradually increasing in the last few decades. However, current diagnostic tools and treatment strategies continue to have limitations. Substantial evidence shows that long noncoding RNAs (lncRNAs) play essential roles in carcinogenesis and the progression, treatment response and prognosis of multiple human cancers, including urological cancers, gastrointestinal tumours, reproductive cancers and respiratory neoplasms. LncRNA small nucleolar RNA host genes (SNHGs), a subgroup of lncRNAs, have been found to be dysregulated in tumour cell biology. In this review, we summarize the impacts of lncRNA SNHGs in urological malignancies and the underlying mechanisms.
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spelling pubmed-81005772021-05-07 Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers Yang, Zitong Li, Qinchen Zheng, Xiangyi Xie, Liping Front Oncol Oncology The incidence of urological cancer has been gradually increasing in the last few decades. However, current diagnostic tools and treatment strategies continue to have limitations. Substantial evidence shows that long noncoding RNAs (lncRNAs) play essential roles in carcinogenesis and the progression, treatment response and prognosis of multiple human cancers, including urological cancers, gastrointestinal tumours, reproductive cancers and respiratory neoplasms. LncRNA small nucleolar RNA host genes (SNHGs), a subgroup of lncRNAs, have been found to be dysregulated in tumour cell biology. In this review, we summarize the impacts of lncRNA SNHGs in urological malignancies and the underlying mechanisms. Frontiers Media S.A. 2021-04-22 /pmc/articles/PMC8100577/ /pubmed/33968736 http://dx.doi.org/10.3389/fonc.2021.638721 Text en Copyright © 2021 Yang, Li, Zheng and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Zitong
Li, Qinchen
Zheng, Xiangyi
Xie, Liping
Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers
title Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers
title_full Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers
title_fullStr Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers
title_full_unstemmed Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers
title_short Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers
title_sort long noncoding rna small nucleolar host gene: a potential therapeutic target in urological cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100577/
https://www.ncbi.nlm.nih.gov/pubmed/33968736
http://dx.doi.org/10.3389/fonc.2021.638721
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AT liqinchen longnoncodingrnasmallnucleolarhostgeneapotentialtherapeutictargetinurologicalcancers
AT zhengxiangyi longnoncodingrnasmallnucleolarhostgeneapotentialtherapeutictargetinurologicalcancers
AT xieliping longnoncodingrnasmallnucleolarhostgeneapotentialtherapeutictargetinurologicalcancers

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