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Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer

We classified clinical phenotypes based on tumor separability from the rectosigmoid colon and then evaluated the effect of these clinical phenotypes on surgical outcomes and prognosis of advanced ovarian cancer. We collected data of patients with stage IIIB-IVB disease who either underwent visceral...

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Autores principales: Park, Soo Jin, Mun, Jaehee, Lee, Eun Ji, Park, Sunwoo, Kim, Sang Youn, Lim, Whasun, Song, Gwonhwa, Kim, Jae-Weon, Lee, Seungmee, Kim, Hee Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100598/
https://www.ncbi.nlm.nih.gov/pubmed/33968784
http://dx.doi.org/10.3389/fonc.2021.673631
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author Park, Soo Jin
Mun, Jaehee
Lee, Eun Ji
Park, Sunwoo
Kim, Sang Youn
Lim, Whasun
Song, Gwonhwa
Kim, Jae-Weon
Lee, Seungmee
Kim, Hee Seung
author_facet Park, Soo Jin
Mun, Jaehee
Lee, Eun Ji
Park, Sunwoo
Kim, Sang Youn
Lim, Whasun
Song, Gwonhwa
Kim, Jae-Weon
Lee, Seungmee
Kim, Hee Seung
author_sort Park, Soo Jin
collection PubMed
description We classified clinical phenotypes based on tumor separability from the rectosigmoid colon and then evaluated the effect of these clinical phenotypes on surgical outcomes and prognosis of advanced ovarian cancer. We collected data of patients with stage IIIB-IVB disease who either underwent visceral segmental serosectomy (VSS) or low anterior resection (LAR) during maximal debulking surgery. All patients were divided into the following, according to the resection types of tumors involving the rectosigmoid colon: the focal (tumor-involved length <18 cm) and separable (FS) group that received VSS, the focal and inseparable (FI) that received LAR, or the diffuse (tumor-involved length ≥18 cm) group (D) that also received LAR. A total of 83 patients were included in FS (n=44, 53%), FI (n=18, 21.7%), and D (n=24, 25.3%) groups. FS and D groups with more extensive tumors were related to wider extent of surgery and more tumor infiltration except for bowels, whereas FI and D groups with more invasive tumors were associated with wider extent of surgery, more tumor infiltration to bowels, longer operation time, more blood loss, more transfusion, longer hospitalization, and higher surgical complexity scores. Moreover, FS and FI groups showed better progression-free survival than D group, whereas FS group demonstrated better overall survival than FI and D groups. Clinical phenotypes based on tumor separability from the rectosigmoid colon may depend on tumor invasiveness and extensiveness in advanced ovarian cancer. Moreover, these clinical phenotypes may affect surgical outcomes and survival.
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spelling pubmed-81005982021-05-07 Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer Park, Soo Jin Mun, Jaehee Lee, Eun Ji Park, Sunwoo Kim, Sang Youn Lim, Whasun Song, Gwonhwa Kim, Jae-Weon Lee, Seungmee Kim, Hee Seung Front Oncol Oncology We classified clinical phenotypes based on tumor separability from the rectosigmoid colon and then evaluated the effect of these clinical phenotypes on surgical outcomes and prognosis of advanced ovarian cancer. We collected data of patients with stage IIIB-IVB disease who either underwent visceral segmental serosectomy (VSS) or low anterior resection (LAR) during maximal debulking surgery. All patients were divided into the following, according to the resection types of tumors involving the rectosigmoid colon: the focal (tumor-involved length <18 cm) and separable (FS) group that received VSS, the focal and inseparable (FI) that received LAR, or the diffuse (tumor-involved length ≥18 cm) group (D) that also received LAR. A total of 83 patients were included in FS (n=44, 53%), FI (n=18, 21.7%), and D (n=24, 25.3%) groups. FS and D groups with more extensive tumors were related to wider extent of surgery and more tumor infiltration except for bowels, whereas FI and D groups with more invasive tumors were associated with wider extent of surgery, more tumor infiltration to bowels, longer operation time, more blood loss, more transfusion, longer hospitalization, and higher surgical complexity scores. Moreover, FS and FI groups showed better progression-free survival than D group, whereas FS group demonstrated better overall survival than FI and D groups. Clinical phenotypes based on tumor separability from the rectosigmoid colon may depend on tumor invasiveness and extensiveness in advanced ovarian cancer. Moreover, these clinical phenotypes may affect surgical outcomes and survival. Frontiers Media S.A. 2021-04-22 /pmc/articles/PMC8100598/ /pubmed/33968784 http://dx.doi.org/10.3389/fonc.2021.673631 Text en Copyright © 2021 Park, Mun, Lee, Park, Kim, Lim, Song, Kim, Lee and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Park, Soo Jin
Mun, Jaehee
Lee, Eun Ji
Park, Sunwoo
Kim, Sang Youn
Lim, Whasun
Song, Gwonhwa
Kim, Jae-Weon
Lee, Seungmee
Kim, Hee Seung
Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
title Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
title_full Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
title_fullStr Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
title_full_unstemmed Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
title_short Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
title_sort clinical phenotypes of tumors invading the rectosigmoid colon affecting the extent of debulking surgery and survival in advanced ovarian cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100598/
https://www.ncbi.nlm.nih.gov/pubmed/33968784
http://dx.doi.org/10.3389/fonc.2021.673631
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