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H. pylori is related to NAFLD but only in female: A Cross-sectional Study

Background: Recently, an increasing number of studies have focused on the extragastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease worldwide that...

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Autores principales: Wang, Jingwei, Dong, Fengxiao, Su, Hui, Zhu, Licun, Shao, Sujun, Wu, Jing, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100637/
https://www.ncbi.nlm.nih.gov/pubmed/33967606
http://dx.doi.org/10.7150/ijms.50748
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author Wang, Jingwei
Dong, Fengxiao
Su, Hui
Zhu, Licun
Shao, Sujun
Wu, Jing
Liu, Hong
author_facet Wang, Jingwei
Dong, Fengxiao
Su, Hui
Zhu, Licun
Shao, Sujun
Wu, Jing
Liu, Hong
author_sort Wang, Jingwei
collection PubMed
description Background: Recently, an increasing number of studies have focused on the extragastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease worldwide that conveys a heavy economic burden on patients and society. The aim of this study was to investigate the relationship between H. pylori and NAFLD and to identify potential influencing factors. Methods: We conducted a cross-sectional study of individuals who had undergone regular physical examinations at the Beijing Shijitan Hospital Health Examination Center from July to October 2018. We evaluated the associations between NAFLD and NAFLD with H. pylori infection and related serum markers using multiple linear regression and logistic regression. Results: There were significant relationships between H. pylori infection status and NAFLD in females (P=0.034) but not in males (P=0.795) according to Fisher's exact test. The association persisted after further adjustment for metabolic variables, gastrin factors, and liver enzymes. Waist-to-Hip Ratio, Body Mass Index, triglycerides, High-density lipoprotein cholesterol, glucose, uric acid, alkaline phosphatase, and Alanine aminotransferase are related to NAFLD after adjusting for age or interaction between biochemical indexes. Conclusion: H. pylori infection is related to NAFLD in female patients. The relationship between H. pylori and NAFLD may be mediated by markers of lipid metabolism and glycometabolism.
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spelling pubmed-81006372021-05-06 H. pylori is related to NAFLD but only in female: A Cross-sectional Study Wang, Jingwei Dong, Fengxiao Su, Hui Zhu, Licun Shao, Sujun Wu, Jing Liu, Hong Int J Med Sci Research Paper Background: Recently, an increasing number of studies have focused on the extragastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease worldwide that conveys a heavy economic burden on patients and society. The aim of this study was to investigate the relationship between H. pylori and NAFLD and to identify potential influencing factors. Methods: We conducted a cross-sectional study of individuals who had undergone regular physical examinations at the Beijing Shijitan Hospital Health Examination Center from July to October 2018. We evaluated the associations between NAFLD and NAFLD with H. pylori infection and related serum markers using multiple linear regression and logistic regression. Results: There were significant relationships between H. pylori infection status and NAFLD in females (P=0.034) but not in males (P=0.795) according to Fisher's exact test. The association persisted after further adjustment for metabolic variables, gastrin factors, and liver enzymes. Waist-to-Hip Ratio, Body Mass Index, triglycerides, High-density lipoprotein cholesterol, glucose, uric acid, alkaline phosphatase, and Alanine aminotransferase are related to NAFLD after adjusting for age or interaction between biochemical indexes. Conclusion: H. pylori infection is related to NAFLD in female patients. The relationship between H. pylori and NAFLD may be mediated by markers of lipid metabolism and glycometabolism. Ivyspring International Publisher 2021-04-02 /pmc/articles/PMC8100637/ /pubmed/33967606 http://dx.doi.org/10.7150/ijms.50748 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Jingwei
Dong, Fengxiao
Su, Hui
Zhu, Licun
Shao, Sujun
Wu, Jing
Liu, Hong
H. pylori is related to NAFLD but only in female: A Cross-sectional Study
title H. pylori is related to NAFLD but only in female: A Cross-sectional Study
title_full H. pylori is related to NAFLD but only in female: A Cross-sectional Study
title_fullStr H. pylori is related to NAFLD but only in female: A Cross-sectional Study
title_full_unstemmed H. pylori is related to NAFLD but only in female: A Cross-sectional Study
title_short H. pylori is related to NAFLD but only in female: A Cross-sectional Study
title_sort h. pylori is related to nafld but only in female: a cross-sectional study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100637/
https://www.ncbi.nlm.nih.gov/pubmed/33967606
http://dx.doi.org/10.7150/ijms.50748
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