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Oncogenic WIP1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis

Wild-type (wt) p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase, Mg(2+)/Mn(2+) dependent 1D (PPM1D) gene, is a serine/threonine phosphatase induced upon genotoxic stress in a p53-dependent manner. Wip1/PPM1D is frequently overexpressed, amplified and mutated in human solid tumors...

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Detalles Bibliográficos
Autores principales:	Eren, Mehtap Kilic, Kartal, Nur Betül, Pilevneli, Hatice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100942/ https://www.ncbi.nlm.nih.gov/pubmed/33968195 http://dx.doi.org/10.3892/ol.2021.12740

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