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Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression
Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed the tumor microenvironment (TME) immune cells to functionally affect the development and progression of breast cancer. However, insufficient evidence of TME immune modulators limit the clinical app...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101191/ https://www.ncbi.nlm.nih.gov/pubmed/33957948 http://dx.doi.org/10.1186/s12964-021-00705-2 |
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author | Jin, Jing Li, Yi Zhao, Qijie Chen, Yue Fu, Shaozhi Wu, JingBo |
author_facet | Jin, Jing Li, Yi Zhao, Qijie Chen, Yue Fu, Shaozhi Wu, JingBo |
author_sort | Jin, Jing |
collection | PubMed |
description | Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed the tumor microenvironment (TME) immune cells to functionally affect the development and progression of breast cancer. However, insufficient evidence of TME immune modulators limit the clinical application of immunotherapy for advanced and metastatic breast cancers. Intercellular STAT3 activation of immune cells plays a central role in breast cancer TME immunosuppression and distant metastasis. Accumulating evidence suggests that targeting STAT3 and/or in combination with radiotherapy may enhance anti-cancer immune responses and rescue the systemic immunologic microenvironment in breast cancer. Indeed, apart from its oncogenic role in tumor cells, the functions of STAT3 in TME of breast cancer involve multiple types of immunosuppression and is associated with tumor cell metastasis. In this review, we summarize the available information on the functions of STAT3-related immune cells in TME of breast cancer, as well as the specific upstream and downstream targets. Additionally, we provide insights about the potential immunosuppression mechanisms of each type of evaluated immune cells. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00705-2. |
format | Online Article Text |
id | pubmed-8101191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81011912021-05-06 Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression Jin, Jing Li, Yi Zhao, Qijie Chen, Yue Fu, Shaozhi Wu, JingBo Cell Commun Signal Review Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed the tumor microenvironment (TME) immune cells to functionally affect the development and progression of breast cancer. However, insufficient evidence of TME immune modulators limit the clinical application of immunotherapy for advanced and metastatic breast cancers. Intercellular STAT3 activation of immune cells plays a central role in breast cancer TME immunosuppression and distant metastasis. Accumulating evidence suggests that targeting STAT3 and/or in combination with radiotherapy may enhance anti-cancer immune responses and rescue the systemic immunologic microenvironment in breast cancer. Indeed, apart from its oncogenic role in tumor cells, the functions of STAT3 in TME of breast cancer involve multiple types of immunosuppression and is associated with tumor cell metastasis. In this review, we summarize the available information on the functions of STAT3-related immune cells in TME of breast cancer, as well as the specific upstream and downstream targets. Additionally, we provide insights about the potential immunosuppression mechanisms of each type of evaluated immune cells. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00705-2. BioMed Central 2021-05-06 /pmc/articles/PMC8101191/ /pubmed/33957948 http://dx.doi.org/10.1186/s12964-021-00705-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Jin, Jing Li, Yi Zhao, Qijie Chen, Yue Fu, Shaozhi Wu, JingBo Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression |
title | Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression |
title_full | Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression |
title_fullStr | Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression |
title_full_unstemmed | Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression |
title_short | Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression |
title_sort | coordinated regulation of immune contexture: crosstalk between stat3 and immune cells during breast cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101191/ https://www.ncbi.nlm.nih.gov/pubmed/33957948 http://dx.doi.org/10.1186/s12964-021-00705-2 |
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