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Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York

It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This...

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Autores principales: Guerson-Gil, Arcelia, Palaiodimos, Leonidas, Assa, Andrei, Karamanis, Dimitris, Kokkinidis, Damianos, Chamorro-Pareja, Natalia, Kishore, Preeti, Leider, Jason M., Brandt, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101338/
https://www.ncbi.nlm.nih.gov/pubmed/33956286
http://dx.doi.org/10.1007/s10096-021-04260-z
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author Guerson-Gil, Arcelia
Palaiodimos, Leonidas
Assa, Andrei
Karamanis, Dimitris
Kokkinidis, Damianos
Chamorro-Pareja, Natalia
Kishore, Preeti
Leider, Jason M.
Brandt, Lawrence J.
author_facet Guerson-Gil, Arcelia
Palaiodimos, Leonidas
Assa, Andrei
Karamanis, Dimitris
Kokkinidis, Damianos
Chamorro-Pareja, Natalia
Kishore, Preeti
Leider, Jason M.
Brandt, Lawrence J.
author_sort Guerson-Gil, Arcelia
collection PubMed
description It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m(2). In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/m(2) and BMI ≥40 kg/m(2) were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m(2) was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04260-z.
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spelling pubmed-81013382021-05-07 Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York Guerson-Gil, Arcelia Palaiodimos, Leonidas Assa, Andrei Karamanis, Dimitris Kokkinidis, Damianos Chamorro-Pareja, Natalia Kishore, Preeti Leider, Jason M. Brandt, Lawrence J. Eur J Clin Microbiol Infect Dis Original Article It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m(2). In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/m(2) and BMI ≥40 kg/m(2) were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m(2) was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04260-z. Springer Berlin Heidelberg 2021-05-06 2021 /pmc/articles/PMC8101338/ /pubmed/33956286 http://dx.doi.org/10.1007/s10096-021-04260-z Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Guerson-Gil, Arcelia
Palaiodimos, Leonidas
Assa, Andrei
Karamanis, Dimitris
Kokkinidis, Damianos
Chamorro-Pareja, Natalia
Kishore, Preeti
Leider, Jason M.
Brandt, Lawrence J.
Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
title Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
title_full Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
title_fullStr Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
title_full_unstemmed Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
title_short Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
title_sort sex-specific impact of severe obesity in the outcomes of hospitalized patients with covid-19: a large retrospective study from the bronx, new york
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101338/
https://www.ncbi.nlm.nih.gov/pubmed/33956286
http://dx.doi.org/10.1007/s10096-021-04260-z
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