DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy

The transmembrane Hsp40 DNAJB12 and cytosolic Hsp70 cooperate on the endoplasmic reticulum’s (ER) cytoplasmic face to facilitate the triage of nascent polytopic membrane proteins for folding versus degradation. N1303K is a common mutation that causes misfolding of the ion channel CFTR, but unlike F5...

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Detalles Bibliográficos
Autores principales: He, Lihua, Kennedy, Andrew S., Houck, Scott, Aleksandrov, Andrei, Quinney, Nancy L., Cyr-Scully, Alexandra, Cholon, Deborah M., Gentzsch, Martina, Randell, Scott H., Ren, Hong Yu, Cyr, Douglas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101465/
https://www.ncbi.nlm.nih.gov/pubmed/33534640
http://dx.doi.org/10.1091/mbc.E20-11-0688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101465/
https://www.ncbi.nlm.nih.gov/pubmed/33534640
http://dx.doi.org/10.1091/mbc.E20-11-0688

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