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Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude o...

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Autores principales: Megasari, Ni Luh Ayu, Utsumi, Takako, Yamani, Laura Navika, Juniastuti, Gunawan, Emily, Furukawa, Koichi, Nishimura, Mitsuhiro, Lusida, Maria Inge, Mori, Yasuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101714/
https://www.ncbi.nlm.nih.gov/pubmed/33956869
http://dx.doi.org/10.1371/journal.pone.0251234
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author Megasari, Ni Luh Ayu
Utsumi, Takako
Yamani, Laura Navika
Juniastuti,
Gunawan, Emily
Furukawa, Koichi
Nishimura, Mitsuhiro
Lusida, Maria Inge
Mori, Yasuko
author_facet Megasari, Ni Luh Ayu
Utsumi, Takako
Yamani, Laura Navika
Juniastuti,
Gunawan, Emily
Furukawa, Koichi
Nishimura, Mitsuhiro
Lusida, Maria Inge
Mori, Yasuko
author_sort Megasari, Ni Luh Ayu
collection PubMed
description Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude of SARS-CoV-2 infection in East Java, Indonesia, we investigated the prevalence of immunoglobulin G (IgG) antibodies. We enrolled 1,819 individuals from June to December 2020 and observed that the subjects’ overall prevalence of IgG antibody to SARS-CoV-2 was 11.4% (207/1,819). The prevalence of anti-SARS-CoV-2 antibodies differed significantly between the job/occupation groups (P = 0.0001). A greater prevalence of IgG was detected in laboratory technicians (who take samples from suspected cases and deal with polymerase chain reaction [PCR] procedures, 22.2%) compared to medical personnel who see and take direct care of patients with COVID-19 (e.g., physicians and nurses, 6.0%), other staff in medical facilities (2.9%), general population (12.1%) and non-COVID-19 patients (14.6%). The highest prevalence among age groups was in the 40–49-year-olds (14.8%), and the lowest prevalence was in the 20–29-year-olds (7.4%). However, the younger population still showed a higher prevalence than generally reported, suggesting greater exposure to the virus but less susceptibility to the disease. A geographical difference was also observed: a higher prevalence in Surabaya (13.1%) than in Jombang (9.9%). In conclusion, the COVID-19 outbreak among asymptomatic populations was characterized by a high prevalence of infection in East Java, Indonesia.
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spelling pubmed-81017142021-05-17 Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia Megasari, Ni Luh Ayu Utsumi, Takako Yamani, Laura Navika Juniastuti, Gunawan, Emily Furukawa, Koichi Nishimura, Mitsuhiro Lusida, Maria Inge Mori, Yasuko PLoS One Research Article Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude of SARS-CoV-2 infection in East Java, Indonesia, we investigated the prevalence of immunoglobulin G (IgG) antibodies. We enrolled 1,819 individuals from June to December 2020 and observed that the subjects’ overall prevalence of IgG antibody to SARS-CoV-2 was 11.4% (207/1,819). The prevalence of anti-SARS-CoV-2 antibodies differed significantly between the job/occupation groups (P = 0.0001). A greater prevalence of IgG was detected in laboratory technicians (who take samples from suspected cases and deal with polymerase chain reaction [PCR] procedures, 22.2%) compared to medical personnel who see and take direct care of patients with COVID-19 (e.g., physicians and nurses, 6.0%), other staff in medical facilities (2.9%), general population (12.1%) and non-COVID-19 patients (14.6%). The highest prevalence among age groups was in the 40–49-year-olds (14.8%), and the lowest prevalence was in the 20–29-year-olds (7.4%). However, the younger population still showed a higher prevalence than generally reported, suggesting greater exposure to the virus but less susceptibility to the disease. A geographical difference was also observed: a higher prevalence in Surabaya (13.1%) than in Jombang (9.9%). In conclusion, the COVID-19 outbreak among asymptomatic populations was characterized by a high prevalence of infection in East Java, Indonesia. Public Library of Science 2021-05-06 /pmc/articles/PMC8101714/ /pubmed/33956869 http://dx.doi.org/10.1371/journal.pone.0251234 Text en © 2021 Megasari et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Megasari, Ni Luh Ayu
Utsumi, Takako
Yamani, Laura Navika
Juniastuti,
Gunawan, Emily
Furukawa, Koichi
Nishimura, Mitsuhiro
Lusida, Maria Inge
Mori, Yasuko
Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
title Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
title_full Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
title_fullStr Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
title_full_unstemmed Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
title_short Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
title_sort seroepidemiological study of sars-cov-2 infection in east java, indonesia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101714/
https://www.ncbi.nlm.nih.gov/pubmed/33956869
http://dx.doi.org/10.1371/journal.pone.0251234
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