Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets

Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used single-cell sequencing to profile SARS-CoV-2-reactive B cells in 38 COVID-19 patients. Using oligo-tagged antigen baits, we isolated B cells speci...

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Detalles Bibliográficos
Autores principales: Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101792/
https://www.ncbi.nlm.nih.gov/pubmed/34022127
http://dx.doi.org/10.1016/j.immuni.2021.05.001

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