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Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials. Clinical trials should be racially and ethnically representative of the population that will eventually benefit from these medications. There are multiple potential...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101938/ https://www.ncbi.nlm.nih.gov/pubmed/33956849 http://dx.doi.org/10.1371/journal.pone.0250735 |
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author | Pischel, Lauren Walelo, Makeda Benson, Jemma Osborn, Rebecca Schrier, Rachel Tuan, Jessica Barakat, Lydia Ogbuagu, Onyema |
author_facet | Pischel, Lauren Walelo, Makeda Benson, Jemma Osborn, Rebecca Schrier, Rachel Tuan, Jessica Barakat, Lydia Ogbuagu, Onyema |
author_sort | Pischel, Lauren |
collection | PubMed |
description | As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials. Clinical trials should be racially and ethnically representative of the population that will eventually benefit from these medications. There are multiple potential barriers to racial and ethnic minority enrollment in clinical trials, one of which could be that inclusion and exclusion criteria select for certain racial or ethnic groups disproportionately. In this observational cohort study at a single health care system, we examined if there were differences in eligibility for treatment with remdesivir based on clinical trial criteria for racial and ethnic minorities compared to non-Hispanic Whites. 201 electronic medical record charts were reviewed manually. Self-identified Whites were older than other racial or ethnic groups. At the time of presentation, Black, Latinx, and White participants met inclusion criteria for remdesivir at similar rates (72%, 80%, and 73% respectively), and exclusion criteria at similar rates (43%, 38% and 49% for Black, Latinx and White participants respectively). In this study, there was no difference in eligibility for remdesivir based on race or ethnicity alone. |
format | Online Article Text |
id | pubmed-8101938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81019382021-05-17 Race and ethnicity do not impact eligibility for remdesivir: A single-center experience Pischel, Lauren Walelo, Makeda Benson, Jemma Osborn, Rebecca Schrier, Rachel Tuan, Jessica Barakat, Lydia Ogbuagu, Onyema PLoS One Research Article As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials. Clinical trials should be racially and ethnically representative of the population that will eventually benefit from these medications. There are multiple potential barriers to racial and ethnic minority enrollment in clinical trials, one of which could be that inclusion and exclusion criteria select for certain racial or ethnic groups disproportionately. In this observational cohort study at a single health care system, we examined if there were differences in eligibility for treatment with remdesivir based on clinical trial criteria for racial and ethnic minorities compared to non-Hispanic Whites. 201 electronic medical record charts were reviewed manually. Self-identified Whites were older than other racial or ethnic groups. At the time of presentation, Black, Latinx, and White participants met inclusion criteria for remdesivir at similar rates (72%, 80%, and 73% respectively), and exclusion criteria at similar rates (43%, 38% and 49% for Black, Latinx and White participants respectively). In this study, there was no difference in eligibility for remdesivir based on race or ethnicity alone. Public Library of Science 2021-05-06 /pmc/articles/PMC8101938/ /pubmed/33956849 http://dx.doi.org/10.1371/journal.pone.0250735 Text en © 2021 Pischel et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Pischel, Lauren Walelo, Makeda Benson, Jemma Osborn, Rebecca Schrier, Rachel Tuan, Jessica Barakat, Lydia Ogbuagu, Onyema Race and ethnicity do not impact eligibility for remdesivir: A single-center experience |
title | Race and ethnicity do not impact eligibility for remdesivir: A single-center experience |
title_full | Race and ethnicity do not impact eligibility for remdesivir: A single-center experience |
title_fullStr | Race and ethnicity do not impact eligibility for remdesivir: A single-center experience |
title_full_unstemmed | Race and ethnicity do not impact eligibility for remdesivir: A single-center experience |
title_short | Race and ethnicity do not impact eligibility for remdesivir: A single-center experience |
title_sort | race and ethnicity do not impact eligibility for remdesivir: a single-center experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101938/ https://www.ncbi.nlm.nih.gov/pubmed/33956849 http://dx.doi.org/10.1371/journal.pone.0250735 |
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