Cargando…

Race and ethnicity do not impact eligibility for remdesivir: A single-center experience

As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials. Clinical trials should be racially and ethnically representative of the population that will eventually benefit from these medications. There are multiple potential...

Descripción completa

Detalles Bibliográficos
Autores principales: Pischel, Lauren, Walelo, Makeda, Benson, Jemma, Osborn, Rebecca, Schrier, Rachel, Tuan, Jessica, Barakat, Lydia, Ogbuagu, Onyema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101938/
https://www.ncbi.nlm.nih.gov/pubmed/33956849
http://dx.doi.org/10.1371/journal.pone.0250735
_version_ 1783689029436309504
author Pischel, Lauren
Walelo, Makeda
Benson, Jemma
Osborn, Rebecca
Schrier, Rachel
Tuan, Jessica
Barakat, Lydia
Ogbuagu, Onyema
author_facet Pischel, Lauren
Walelo, Makeda
Benson, Jemma
Osborn, Rebecca
Schrier, Rachel
Tuan, Jessica
Barakat, Lydia
Ogbuagu, Onyema
author_sort Pischel, Lauren
collection PubMed
description As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials. Clinical trials should be racially and ethnically representative of the population that will eventually benefit from these medications. There are multiple potential barriers to racial and ethnic minority enrollment in clinical trials, one of which could be that inclusion and exclusion criteria select for certain racial or ethnic groups disproportionately. In this observational cohort study at a single health care system, we examined if there were differences in eligibility for treatment with remdesivir based on clinical trial criteria for racial and ethnic minorities compared to non-Hispanic Whites. 201 electronic medical record charts were reviewed manually. Self-identified Whites were older than other racial or ethnic groups. At the time of presentation, Black, Latinx, and White participants met inclusion criteria for remdesivir at similar rates (72%, 80%, and 73% respectively), and exclusion criteria at similar rates (43%, 38% and 49% for Black, Latinx and White participants respectively). In this study, there was no difference in eligibility for remdesivir based on race or ethnicity alone.
format Online
Article
Text
id pubmed-8101938
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-81019382021-05-17 Race and ethnicity do not impact eligibility for remdesivir: A single-center experience Pischel, Lauren Walelo, Makeda Benson, Jemma Osborn, Rebecca Schrier, Rachel Tuan, Jessica Barakat, Lydia Ogbuagu, Onyema PLoS One Research Article As the Coronavirus-2019 (COVID-19) pandemic continues, multiple therapies are rapidly being evaluated for efficacy in clinical trials. Clinical trials should be racially and ethnically representative of the population that will eventually benefit from these medications. There are multiple potential barriers to racial and ethnic minority enrollment in clinical trials, one of which could be that inclusion and exclusion criteria select for certain racial or ethnic groups disproportionately. In this observational cohort study at a single health care system, we examined if there were differences in eligibility for treatment with remdesivir based on clinical trial criteria for racial and ethnic minorities compared to non-Hispanic Whites. 201 electronic medical record charts were reviewed manually. Self-identified Whites were older than other racial or ethnic groups. At the time of presentation, Black, Latinx, and White participants met inclusion criteria for remdesivir at similar rates (72%, 80%, and 73% respectively), and exclusion criteria at similar rates (43%, 38% and 49% for Black, Latinx and White participants respectively). In this study, there was no difference in eligibility for remdesivir based on race or ethnicity alone. Public Library of Science 2021-05-06 /pmc/articles/PMC8101938/ /pubmed/33956849 http://dx.doi.org/10.1371/journal.pone.0250735 Text en © 2021 Pischel et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pischel, Lauren
Walelo, Makeda
Benson, Jemma
Osborn, Rebecca
Schrier, Rachel
Tuan, Jessica
Barakat, Lydia
Ogbuagu, Onyema
Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
title Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
title_full Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
title_fullStr Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
title_full_unstemmed Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
title_short Race and ethnicity do not impact eligibility for remdesivir: A single-center experience
title_sort race and ethnicity do not impact eligibility for remdesivir: a single-center experience
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101938/
https://www.ncbi.nlm.nih.gov/pubmed/33956849
http://dx.doi.org/10.1371/journal.pone.0250735
work_keys_str_mv AT pischellauren raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT walelomakeda raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT bensonjemma raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT osbornrebecca raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT schrierrachel raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT tuanjessica raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT barakatlydia raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience
AT ogbuaguonyema raceandethnicitydonotimpacteligibilityforremdesivirasinglecenterexperience