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Factors associated with prematurity in reported cases of congenital syphilis

OBJECTIVE: To analyze the factors associated with prematurity in reported cases of congenital syphilis in the city of Fortaleza, Ceará, Brazil. METHODS: Cross-sectional study conducted in ten public maternity hospitals in Fortaleza, Ceará, Brazil. A total of 478 reported cases of congenital syphilis...

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Autores principales: Araújo, Maria Alix Leite, Esteves, Ana Beatriz Barbosa, Rocha, Ana Fátima Braga, da Silva, Geraldo Bezerra, Miranda, Angelica Espinosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Saúde Pública da Universidade de São Paulo 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102023/
https://www.ncbi.nlm.nih.gov/pubmed/34008782
http://dx.doi.org/10.11606/s1518-8787.2021055002400
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author Araújo, Maria Alix Leite
Esteves, Ana Beatriz Barbosa
Rocha, Ana Fátima Braga
da Silva, Geraldo Bezerra
Miranda, Angelica Espinosa
author_facet Araújo, Maria Alix Leite
Esteves, Ana Beatriz Barbosa
Rocha, Ana Fátima Braga
da Silva, Geraldo Bezerra
Miranda, Angelica Espinosa
author_sort Araújo, Maria Alix Leite
collection PubMed
description OBJECTIVE: To analyze the factors associated with prematurity in reported cases of congenital syphilis in the city of Fortaleza, Ceará, Brazil. METHODS: Cross-sectional study conducted in ten public maternity hospitals in Fortaleza, Ceará, Brazil. A total of 478 reported cases of congenital syphilis were included in 2015, and data were collected from notification forms, from mothers’ and babies’ medical records and from prenatal cards. For the bivariate analysis, Pearson’s chi-squared and Fisher’s exact tests were used, considering p < 0.05. Multiple logistic regression was conducted, presenting odds ratio (OR) with a 95% confidence interval. RESULTS: We found 15.3% prematurity in pregnant women with syphilis. The titration of the VDRL test > 1:8 at delivery (OR 2.46; 95%CI: 1.33–4.53; p = 0.004) and the non-treatment of the pregnant women or treatment with drugs other than penicillin during prenatal care (OR 3.52; 95%CI: 1.74–7.13; p< 0.001) were associated with higher chances of prematurity. CONCLUSION: The prematurity due to congenital syphilis is a preventable condition, provided that pregnant women with syphilis are treated appropriately. Weaknesses in prenatal care are associated with this outcome, which highlights the importance of public policies oriented to improve the quality of prenatal care.
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spelling pubmed-81020232021-05-07 Factors associated with prematurity in reported cases of congenital syphilis Araújo, Maria Alix Leite Esteves, Ana Beatriz Barbosa Rocha, Ana Fátima Braga da Silva, Geraldo Bezerra Miranda, Angelica Espinosa Rev Saude Publica Original Article OBJECTIVE: To analyze the factors associated with prematurity in reported cases of congenital syphilis in the city of Fortaleza, Ceará, Brazil. METHODS: Cross-sectional study conducted in ten public maternity hospitals in Fortaleza, Ceará, Brazil. A total of 478 reported cases of congenital syphilis were included in 2015, and data were collected from notification forms, from mothers’ and babies’ medical records and from prenatal cards. For the bivariate analysis, Pearson’s chi-squared and Fisher’s exact tests were used, considering p < 0.05. Multiple logistic regression was conducted, presenting odds ratio (OR) with a 95% confidence interval. RESULTS: We found 15.3% prematurity in pregnant women with syphilis. The titration of the VDRL test > 1:8 at delivery (OR 2.46; 95%CI: 1.33–4.53; p = 0.004) and the non-treatment of the pregnant women or treatment with drugs other than penicillin during prenatal care (OR 3.52; 95%CI: 1.74–7.13; p< 0.001) were associated with higher chances of prematurity. CONCLUSION: The prematurity due to congenital syphilis is a preventable condition, provided that pregnant women with syphilis are treated appropriately. Weaknesses in prenatal care are associated with this outcome, which highlights the importance of public policies oriented to improve the quality of prenatal care. Faculdade de Saúde Pública da Universidade de São Paulo 2021-05-06 /pmc/articles/PMC8102023/ /pubmed/34008782 http://dx.doi.org/10.11606/s1518-8787.2021055002400 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Araújo, Maria Alix Leite
Esteves, Ana Beatriz Barbosa
Rocha, Ana Fátima Braga
da Silva, Geraldo Bezerra
Miranda, Angelica Espinosa
Factors associated with prematurity in reported cases of congenital syphilis
title Factors associated with prematurity in reported cases of congenital syphilis
title_full Factors associated with prematurity in reported cases of congenital syphilis
title_fullStr Factors associated with prematurity in reported cases of congenital syphilis
title_full_unstemmed Factors associated with prematurity in reported cases of congenital syphilis
title_short Factors associated with prematurity in reported cases of congenital syphilis
title_sort factors associated with prematurity in reported cases of congenital syphilis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102023/
https://www.ncbi.nlm.nih.gov/pubmed/34008782
http://dx.doi.org/10.11606/s1518-8787.2021055002400
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