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Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience

In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions....

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Autores principales: Fengler, Alexander, Govindarajan, Lakshmi N, Chen, Tony, Frank, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102064/
https://www.ncbi.nlm.nih.gov/pubmed/33821788
http://dx.doi.org/10.7554/eLife.65074
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author Fengler, Alexander
Govindarajan, Lakshmi N
Chen, Tony
Frank, Michael J
author_facet Fengler, Alexander
Govindarajan, Lakshmi N
Chen, Tony
Frank, Michael J
author_sort Fengler, Alexander
collection PubMed
description In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training.
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spelling pubmed-81020642021-05-11 Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience Fengler, Alexander Govindarajan, Lakshmi N Chen, Tony Frank, Michael J eLife Neuroscience In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training. eLife Sciences Publications, Ltd 2021-04-06 /pmc/articles/PMC8102064/ /pubmed/33821788 http://dx.doi.org/10.7554/eLife.65074 Text en © 2021, Fengler et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Fengler, Alexander
Govindarajan, Lakshmi N
Chen, Tony
Frank, Michael J
Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
title Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
title_full Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
title_fullStr Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
title_full_unstemmed Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
title_short Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
title_sort likelihood approximation networks (lans) for fast inference of simulation models in cognitive neuroscience
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102064/
https://www.ncbi.nlm.nih.gov/pubmed/33821788
http://dx.doi.org/10.7554/eLife.65074
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