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Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience
In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102064/ https://www.ncbi.nlm.nih.gov/pubmed/33821788 http://dx.doi.org/10.7554/eLife.65074 |
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author | Fengler, Alexander Govindarajan, Lakshmi N Chen, Tony Frank, Michael J |
author_facet | Fengler, Alexander Govindarajan, Lakshmi N Chen, Tony Frank, Michael J |
author_sort | Fengler, Alexander |
collection | PubMed |
description | In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training. |
format | Online Article Text |
id | pubmed-8102064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81020642021-05-11 Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience Fengler, Alexander Govindarajan, Lakshmi N Chen, Tony Frank, Michael J eLife Neuroscience In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training. eLife Sciences Publications, Ltd 2021-04-06 /pmc/articles/PMC8102064/ /pubmed/33821788 http://dx.doi.org/10.7554/eLife.65074 Text en © 2021, Fengler et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Fengler, Alexander Govindarajan, Lakshmi N Chen, Tony Frank, Michael J Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience |
title | Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience |
title_full | Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience |
title_fullStr | Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience |
title_full_unstemmed | Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience |
title_short | Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience |
title_sort | likelihood approximation networks (lans) for fast inference of simulation models in cognitive neuroscience |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102064/ https://www.ncbi.nlm.nih.gov/pubmed/33821788 http://dx.doi.org/10.7554/eLife.65074 |
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