Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia

Children of Hispanic/Latino ancestry have increased incidence of high-risk B-cell acute lymphoblastic leukemia (HR B-ALL) with poor prognosis. This leukemia is characterized by a single-copy deletion of the IKZF1 (IKAROS) tumor suppressor and increased activation of the PI3K/AKT/mTOR pathway. This i...

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Detalles Bibliográficos
Autores principales: Ge, Zheng, Song, Chunhua, Ding, Yali, Tan, Bi-Hua, Desai, Dhimant, Sharma, Arati, Gowda, Raghavendra, Yue, Feng, Huang, Suming, Spiegelman, Vladimir, Payne, Jonathon L., Reeves, Mark E., Iyer, Soumya, Dhanyamraju, Pavan Kumar, Imamura, Yuka, Bogush, Daniel, Bamme, Yevgeniya, Yang, Yiping, Soliman, Mario, Kane, Shriya, Dovat, Elanora, Schramm, Joseph, Hu, Tommy, McGrath, Mary, Chroneos, Zissis C., Payne, Kimberly J., Gowda, Chandrika, Dovat, Sinisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102195/
https://www.ncbi.nlm.nih.gov/pubmed/33531656
http://dx.doi.org/10.1038/s41375-021-01132-5

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