O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity

A major role for the intracellular posttranslational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies in this area have focused on O-GlcNAc modification of the amyloid-forming proteins themselves. Here, we use synthetic protein chemistry to disc...

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Detalles Bibliográficos
Autores principales: Balana, Aaron T., Levine, Paul M., Craven, Timothy W., Mukherjee, Somnath, Pedowitz, Nichole J., Moon, Stuart P., Takahashi, Terry T., Becker, Christian F. W., Baker, David, Pratt, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102337/
https://www.ncbi.nlm.nih.gov/pubmed/33723378
http://dx.doi.org/10.1038/s41557-021-00648-8

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