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Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern
INTRODUCTION: Pregnancy is associated with changes in bone remodeling and calcium metabolism, which may increase the risk of fragility fracture after menopause. We hypothesized that in postmenopausal women, with history of grand multiparity, the magnitude of trabecular bone deterioration is associat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102397/ https://www.ncbi.nlm.nih.gov/pubmed/33997148 http://dx.doi.org/10.1016/j.bonr.2021.101071 |
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author | Panahi, Nekoo Ostovar, Afshin Fahimfar, Noushin Gharibzadeh, Safoora Shafiee, Gita Heshmat, Ramin Raeisi, Alireza Nabipour, Iraj Larijani, Bagher Ghasem-Zadeh, Ali |
author_facet | Panahi, Nekoo Ostovar, Afshin Fahimfar, Noushin Gharibzadeh, Safoora Shafiee, Gita Heshmat, Ramin Raeisi, Alireza Nabipour, Iraj Larijani, Bagher Ghasem-Zadeh, Ali |
author_sort | Panahi, Nekoo |
collection | PubMed |
description | INTRODUCTION: Pregnancy is associated with changes in bone remodeling and calcium metabolism, which may increase the risk of fragility fracture after menopause. We hypothesized that in postmenopausal women, with history of grand multiparity, the magnitude of trabecular bone deterioration is associated with number of deliveries. METHODS: 1217 women aged 69.2 ± 6.4 years, from the Bushehr Elderly Health (BEH) program were recruited. The areal bone mineral density (aBMD) of the lumbar spine and femoral neck and trabecular bone score (TBS) of 916 postmenopausal women, with grand multiparity defined as more than 4 deliveries, were compared with those of 301 postmenopausal women with 4 or fewer deliveries. The association of multiparity with aBMDs and TBS were evaluated after adjustment for possible confounders including age, years since menopause, body mass index, and other relevant parameters. RESULTS: The aBMD of femoral neck (0.583 ± 0.110 vs. 0.603 ± 0.113 g/cm(2)), lumbar spine (0.805 ± 0.144 vs. 0.829 ± 0.140 g/cm(2)) and TBS (1.234 ± 0.086 vs. 1.260 ± 0.089) were significantly lower in women with history of grand multiparity than others. In the multiple regression analysis, after adjusting for confounders, the negative association did persist for lumbar spine aBMD (beta = −0.02, p value = 0.01), and the TBS (beta = −0.01, p value = 0.03), not for femoral neck aBMD. CONCLUSION: We infer that grand multiparity have deleterious effects on the aBMD and the trabecular pattern of the lumbar spine. |
format | Online Article Text |
id | pubmed-8102397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81023972021-05-14 Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern Panahi, Nekoo Ostovar, Afshin Fahimfar, Noushin Gharibzadeh, Safoora Shafiee, Gita Heshmat, Ramin Raeisi, Alireza Nabipour, Iraj Larijani, Bagher Ghasem-Zadeh, Ali Bone Rep Article INTRODUCTION: Pregnancy is associated with changes in bone remodeling and calcium metabolism, which may increase the risk of fragility fracture after menopause. We hypothesized that in postmenopausal women, with history of grand multiparity, the magnitude of trabecular bone deterioration is associated with number of deliveries. METHODS: 1217 women aged 69.2 ± 6.4 years, from the Bushehr Elderly Health (BEH) program were recruited. The areal bone mineral density (aBMD) of the lumbar spine and femoral neck and trabecular bone score (TBS) of 916 postmenopausal women, with grand multiparity defined as more than 4 deliveries, were compared with those of 301 postmenopausal women with 4 or fewer deliveries. The association of multiparity with aBMDs and TBS were evaluated after adjustment for possible confounders including age, years since menopause, body mass index, and other relevant parameters. RESULTS: The aBMD of femoral neck (0.583 ± 0.110 vs. 0.603 ± 0.113 g/cm(2)), lumbar spine (0.805 ± 0.144 vs. 0.829 ± 0.140 g/cm(2)) and TBS (1.234 ± 0.086 vs. 1.260 ± 0.089) were significantly lower in women with history of grand multiparity than others. In the multiple regression analysis, after adjusting for confounders, the negative association did persist for lumbar spine aBMD (beta = −0.02, p value = 0.01), and the TBS (beta = −0.01, p value = 0.03), not for femoral neck aBMD. CONCLUSION: We infer that grand multiparity have deleterious effects on the aBMD and the trabecular pattern of the lumbar spine. Elsevier 2021-04-22 /pmc/articles/PMC8102397/ /pubmed/33997148 http://dx.doi.org/10.1016/j.bonr.2021.101071 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Panahi, Nekoo Ostovar, Afshin Fahimfar, Noushin Gharibzadeh, Safoora Shafiee, Gita Heshmat, Ramin Raeisi, Alireza Nabipour, Iraj Larijani, Bagher Ghasem-Zadeh, Ali Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
title | Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
title_full | Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
title_fullStr | Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
title_full_unstemmed | Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
title_short | Grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
title_sort | grand multiparity associations with low bone mineral density and degraded trabecular bone pattern |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102397/ https://www.ncbi.nlm.nih.gov/pubmed/33997148 http://dx.doi.org/10.1016/j.bonr.2021.101071 |
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