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Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps
Hamish Small, scientist extraordinaire, is best known as the inventor of both ion chromatography and hydrodynamic chromatography (HDC). The latter has experienced a renaissance during the last decade-plus, thanks principally to its coupling to a multiplicity of physicochemical detection methods and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102424/ https://www.ncbi.nlm.nih.gov/pubmed/33997367 http://dx.doi.org/10.1016/j.heliyon.2021.e06691 |
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author | Striegel, André M. |
author_facet | Striegel, André M. |
author_sort | Striegel, André M. |
collection | PubMed |
description | Hamish Small, scientist extraordinaire, is best known as the inventor of both ion chromatography and hydrodynamic chromatography (HDC). The latter has experienced a renaissance during the last decade-plus, thanks principally to its coupling to a multiplicity of physicochemical detection methods and to the structural and compositional information this provides. Detection methods such as light scattering (both multi-angle static and dynamic), viscometry, and refractometry can combine to yield insight into macromolecular or colloidal size, structure, shape, and molar mass, all as a function of one another and continuously across a sample's chromatogram. It was the author's great fortune to have known Hamish during the last decade of his life, before his passing in 2019. Here, a brief personal recollection is followed by an introduction to HDC and its application, in quadruple-detector packed-column mode, to the analysis of a commercial colloidal silica with an elongated shape. |
format | Online Article Text |
id | pubmed-8102424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81024242021-05-14 Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps Striegel, André M. Heliyon Review Article Hamish Small, scientist extraordinaire, is best known as the inventor of both ion chromatography and hydrodynamic chromatography (HDC). The latter has experienced a renaissance during the last decade-plus, thanks principally to its coupling to a multiplicity of physicochemical detection methods and to the structural and compositional information this provides. Detection methods such as light scattering (both multi-angle static and dynamic), viscometry, and refractometry can combine to yield insight into macromolecular or colloidal size, structure, shape, and molar mass, all as a function of one another and continuously across a sample's chromatogram. It was the author's great fortune to have known Hamish during the last decade of his life, before his passing in 2019. Here, a brief personal recollection is followed by an introduction to HDC and its application, in quadruple-detector packed-column mode, to the analysis of a commercial colloidal silica with an elongated shape. Elsevier 2021-04-27 /pmc/articles/PMC8102424/ /pubmed/33997367 http://dx.doi.org/10.1016/j.heliyon.2021.e06691 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Striegel, André M. Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps |
title | Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps |
title_full | Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps |
title_fullStr | Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps |
title_full_unstemmed | Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps |
title_short | Multi-detector hydrodynamic chromatography of colloids: following in Hamish Small's footsteps |
title_sort | multi-detector hydrodynamic chromatography of colloids: following in hamish small's footsteps |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102424/ https://www.ncbi.nlm.nih.gov/pubmed/33997367 http://dx.doi.org/10.1016/j.heliyon.2021.e06691 |
work_keys_str_mv | AT striegelandrem multidetectorhydrodynamicchromatographyofcolloidsfollowinginhamishsmallsfootsteps |