The p53-caspase-2 axis in the cell cycle and DNA damage response

Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of...

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Autores principales: Lim, Yoon, Dorstyn, Loretta, Kumar, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102494/
https://www.ncbi.nlm.nih.gov/pubmed/33854186
http://dx.doi.org/10.1038/s12276-021-00590-2
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author Lim, Yoon
Dorstyn, Loretta
Kumar, Sharad
author_facet Lim, Yoon
Dorstyn, Loretta
Kumar, Sharad
author_sort Lim, Yoon
collection PubMed
description Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. A number of recent studies suggest that caspase-2 plays an important role in the regulation of p53 in response to cellular stress and DNA damage to prevent the proliferation and accumulation of damaged or aberrant cells. Here, we review these recent observations and their implications in caspase-2-mediated cellular death, senescence, and tumor suppression.
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spelling pubmed-81024942021-05-24 The p53-caspase-2 axis in the cell cycle and DNA damage response Lim, Yoon Dorstyn, Loretta Kumar, Sharad Exp Mol Med Review Article Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. A number of recent studies suggest that caspase-2 plays an important role in the regulation of p53 in response to cellular stress and DNA damage to prevent the proliferation and accumulation of damaged or aberrant cells. Here, we review these recent observations and their implications in caspase-2-mediated cellular death, senescence, and tumor suppression. Nature Publishing Group UK 2021-04-14 /pmc/articles/PMC8102494/ /pubmed/33854186 http://dx.doi.org/10.1038/s12276-021-00590-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Lim, Yoon
Dorstyn, Loretta
Kumar, Sharad
The p53-caspase-2 axis in the cell cycle and DNA damage response
title The p53-caspase-2 axis in the cell cycle and DNA damage response
title_full The p53-caspase-2 axis in the cell cycle and DNA damage response
title_fullStr The p53-caspase-2 axis in the cell cycle and DNA damage response
title_full_unstemmed The p53-caspase-2 axis in the cell cycle and DNA damage response
title_short The p53-caspase-2 axis in the cell cycle and DNA damage response
title_sort p53-caspase-2 axis in the cell cycle and dna damage response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102494/
https://www.ncbi.nlm.nih.gov/pubmed/33854186
http://dx.doi.org/10.1038/s12276-021-00590-2
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