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Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group
Males and females show different patterns of cannabis use and related psychosocial outcomes. However, the neuroanatomical substrates underlying such differences are poorly understood. The aim of this study was to map sex differences in the neurobiology (as indexed by brain volumes) of dependent and...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102553/ https://www.ncbi.nlm.nih.gov/pubmed/33958576 http://dx.doi.org/10.1038/s41398-021-01382-y |
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author | Rossetti, Maria Gloria Mackey, Scott Patalay, Praveetha Allen, Nicholas B. Batalla, Albert Bellani, Marcella Chye, Yann Conrod, Patricia Cousijn, Janna Garavan, Hugh Goudriaan, Anna E. Hester, Robert Martin-Santos, Rocio Solowij, Nadia Suo, Chao Thompson, Paul M. Yücel, Murat Brambilla, Paolo Lorenzetti, Valentina |
author_facet | Rossetti, Maria Gloria Mackey, Scott Patalay, Praveetha Allen, Nicholas B. Batalla, Albert Bellani, Marcella Chye, Yann Conrod, Patricia Cousijn, Janna Garavan, Hugh Goudriaan, Anna E. Hester, Robert Martin-Santos, Rocio Solowij, Nadia Suo, Chao Thompson, Paul M. Yücel, Murat Brambilla, Paolo Lorenzetti, Valentina |
author_sort | Rossetti, Maria Gloria |
collection | PubMed |
description | Males and females show different patterns of cannabis use and related psychosocial outcomes. However, the neuroanatomical substrates underlying such differences are poorly understood. The aim of this study was to map sex differences in the neurobiology (as indexed by brain volumes) of dependent and recreational cannabis use. We compared the volume of a priori regions of interest (i.e., amygdala, hippocampus, nucleus accumbens, insula, orbitofrontal cortex (OFC), anterior cingulate cortex and cerebellum) between 129 regular cannabis users (of whom 70 were recreational users and 59 cannabis dependent) and 114 controls recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age, IQ, and alcohol and tobacco use. Dependent cannabis users, particularly females, had (marginally significant) smaller volumes of the lateral OFC and cerebellar white matter than recreational users and controls. In dependent (but not recreational) cannabis users, there was a significant association between female sex and smaller volumes of the cerebellar white matter and OFC. Volume of the OFC was also predicted by monthly standard drinks. No significant effects emerged the other brain regions of interest. Our findings warrant future multimodal studies that examine if sex and cannabis dependence are specific key drivers of neurobiological alterations in cannabis users. This, in turn, could help to identify neural pathways specifically involved in vulnerable cannabis users (e.g., females with cannabis dependence) and inform individually tailored neurobiological targets for treatment. |
format | Online Article Text |
id | pubmed-8102553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81025532021-05-10 Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group Rossetti, Maria Gloria Mackey, Scott Patalay, Praveetha Allen, Nicholas B. Batalla, Albert Bellani, Marcella Chye, Yann Conrod, Patricia Cousijn, Janna Garavan, Hugh Goudriaan, Anna E. Hester, Robert Martin-Santos, Rocio Solowij, Nadia Suo, Chao Thompson, Paul M. Yücel, Murat Brambilla, Paolo Lorenzetti, Valentina Transl Psychiatry Article Males and females show different patterns of cannabis use and related psychosocial outcomes. However, the neuroanatomical substrates underlying such differences are poorly understood. The aim of this study was to map sex differences in the neurobiology (as indexed by brain volumes) of dependent and recreational cannabis use. We compared the volume of a priori regions of interest (i.e., amygdala, hippocampus, nucleus accumbens, insula, orbitofrontal cortex (OFC), anterior cingulate cortex and cerebellum) between 129 regular cannabis users (of whom 70 were recreational users and 59 cannabis dependent) and 114 controls recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age, IQ, and alcohol and tobacco use. Dependent cannabis users, particularly females, had (marginally significant) smaller volumes of the lateral OFC and cerebellar white matter than recreational users and controls. In dependent (but not recreational) cannabis users, there was a significant association between female sex and smaller volumes of the cerebellar white matter and OFC. Volume of the OFC was also predicted by monthly standard drinks. No significant effects emerged the other brain regions of interest. Our findings warrant future multimodal studies that examine if sex and cannabis dependence are specific key drivers of neurobiological alterations in cannabis users. This, in turn, could help to identify neural pathways specifically involved in vulnerable cannabis users (e.g., females with cannabis dependence) and inform individually tailored neurobiological targets for treatment. Nature Publishing Group UK 2021-05-06 /pmc/articles/PMC8102553/ /pubmed/33958576 http://dx.doi.org/10.1038/s41398-021-01382-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rossetti, Maria Gloria Mackey, Scott Patalay, Praveetha Allen, Nicholas B. Batalla, Albert Bellani, Marcella Chye, Yann Conrod, Patricia Cousijn, Janna Garavan, Hugh Goudriaan, Anna E. Hester, Robert Martin-Santos, Rocio Solowij, Nadia Suo, Chao Thompson, Paul M. Yücel, Murat Brambilla, Paolo Lorenzetti, Valentina Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group |
title | Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group |
title_full | Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group |
title_fullStr | Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group |
title_full_unstemmed | Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group |
title_short | Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group |
title_sort | sex and dependence related neuroanatomical differences in regular cannabis users: findings from the enigma addiction working group |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102553/ https://www.ncbi.nlm.nih.gov/pubmed/33958576 http://dx.doi.org/10.1038/s41398-021-01382-y |
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