A bioactive molecule made by unusual salvage of radical SAM enzyme byproduct 5-deoxyadenosine blurs the boundary of primary and secondary metabolism

5-Deoxyadenosine (5dAdo) is the byproduct of many radical S-adenosyl-l-methionine enzyme reactions in all domains of life. 5dAdo is also an inhibitor of the radical S-adenosyl-l-methionine enzymes themselves, making it necessary for cells to construct pathways to recycle or dispose of this toxic met...

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Detalles Bibliográficos
Autores principales: Rapp, Johanna, Rath, Pascal, Kilian, Joachim, Brilisauer, Klaus, Grond, Stephanie, Forchhammer, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102628/
https://www.ncbi.nlm.nih.gov/pubmed/33811856
http://dx.doi.org/10.1016/j.jbc.2021.100621

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