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Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex

CRISPR-Cas systems provide adaptive immunity in bacteria and archaea, beginning with integration of foreign sequences into the host CRISPR genomic locus and followed by transcription and maturation of CRISPR RNAs (crRNAs). In some CRISPR systems, a reverse transcriptase (RT) fusion to the Cas1 integ...

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Detalles Bibliográficos
Autores principales:	Wang, Joy Y., Hoel, Christopher M., Al-Shayeb, Basem, Banfield, Jillian F., Brohawn, Stephen G., Doudna, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102632/ https://www.ncbi.nlm.nih.gov/pubmed/33958590 http://dx.doi.org/10.1038/s41467-021-22900-y

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