Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response

Abnormally increased resorption contributes to bone degenerative diseases such as Paget’s disease of bone (PDB) through unclear mechanisms. Recently, the optineurin (OPTN) gene has been implicated in PDB, and global OPTN knockout mice (Optn(−/−)) were shown to exhibit increased formation of osteocla...

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Detalles Bibliográficos
Autores principales: Xue, Peng, Hu, Xiangxiang, Chang, Emily, Wang, Lufei, Chen, Minghui, Wu, Tai-Hsien, Lee, Dong-Joon, Foster, Brian L., Tseng, Henry C., Ko, Ching-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102640/
https://www.ncbi.nlm.nih.gov/pubmed/33864025
http://dx.doi.org/10.1038/s12276-021-00596-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102640/
https://www.ncbi.nlm.nih.gov/pubmed/33864025
http://dx.doi.org/10.1038/s12276-021-00596-w

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