Cargando…

Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response

Abnormally increased resorption contributes to bone degenerative diseases such as Paget’s disease of bone (PDB) through unclear mechanisms. Recently, the optineurin (OPTN) gene has been implicated in PDB, and global OPTN knockout mice (Optn(−/−)) were shown to exhibit increased formation of osteocla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Peng, Hu, Xiangxiang, Chang, Emily, Wang, Lufei, Chen, Minghui, Wu, Tai-Hsien, Lee, Dong-Joon, Foster, Brian L., Tseng, Henry C., Ko, Ching-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102640/ https://www.ncbi.nlm.nih.gov/pubmed/33864025 http://dx.doi.org/10.1038/s12276-021-00596-w

Ejemplares similares

Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget’s disease of bone
por: Hu, Xiangxiang, et al.
Publicado: (2023)

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease
por: Obaid, Rami, et al.
Publicado: (2015)

Optineurin Functions for Optimal Immunity
por: Slowicka, Karolina, et al.
Publicado: (2018)

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels
por: Prtenjaca, Nikolina, et al.
Publicado: (2022)

Novel mutation in optineurin causing aggressive ALS+/−frontotemporal dementia
por: Feng, Shu‐Man, et al.
Publicado: (2019)

Effects of mutations and deletions in the human optineurin gene
por: Turturro, Sanja, et al.
Publicado: (2014)

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma
por: Toth, Reka P., et al.
Publicado: (2018)

The Selective Autophagy Receptor Optineurin in Crohn’s Disease
por: Tschurtschenthaler, Markus, et al.
Publicado: (2018)

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis
por: Chew, Thean S., et al.
Publicado: (2015)

Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin
por: Park, BumChan, et al.
Publicado: (2010)

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin
por: Swarup, Ghanshyam, et al.
Publicado: (2018)

The Role of Optineurin in Antiviral Type I Interferon Production
por: Outlioua, Ahmed, et al.
Publicado: (2018)

Editorial: The Role of Optineurin in Immunity and Immune-Mediated Diseases
por: Smith, Andrew M., et al.
Publicado: (2019)

Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration
por: Hu, Zhilei, et al.
Publicado: (2022)

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection
por: Fukushi, Masaya, et al.
Publicado: (2023)

Variation in optineurin (OPTN) allele frequencies between and within populations
por: Ayala-Lugo, Rosa M., et al.
Publicado: (2007)

Myocilin and optineurin coding variants in Hispanics of Mexican Descent with POAG
por: McDonald, Kristin K., et al.
Publicado: (2010)

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy
por: Ryan, Thomas A., et al.
Publicado: (2018)

PINK1‐mediated mitophagy maintains pluripotency through optineurin
por: Wang, Chaoqun, et al.
Publicado: (2021)

Neuroimmune characterization of optineurin insufficiency mouse model during ageing
por: Mohovic, Nikolina, et al.
Publicado: (2023)

Absence of optineurin (OPTN) gene mutations in Taiwanese patients with juvenile-onset open-angle glaucoma
por: Yen, Yung-Chang, et al.
Publicado: (2008)

Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma
por: Liu, Yutao, et al.
Publicado: (2008)

Absence of altered expression of optineurin in primary open angle glaucoma patients
por: Abu-Amero, Khaled K., et al.
Publicado: (2012)

Myosin VI and Optineurin Are Required for Polarized EGFR Delivery and Directed Migration
por: Chibalina, Margarita V, et al.
Publicado: (2010)

Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner
por: Génin, Pierre, et al.
Publicado: (2015)

Molecular analysis of myocilin and optineurin genes in Korean primary glaucoma patients
por: Park, Joonhong, et al.
Publicado: (2016)

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
por: Nakazawa, Seshiru, et al.
Publicado: (2016)

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer
por: Weil, Robert, et al.
Publicado: (2018)

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
por: Evans, Chantell S, et al.
Publicado: (2020)

Chicken optineurin suppresses MDA5-mediated interferon β production
por: Li, Yu, et al.
Publicado: (2020)

Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagy
por: Inokuchi, Shoichi, et al.
Publicado: (2021)

A rare optineurin mutation in an Indian family with coexistence of JOAG and PCG
por: Yadav, Manoj, et al.
Publicado: (2023)

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin
por: Sirohi, Kapil, et al.
Publicado: (2015)

Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation
por: Yamaguchi, Yuuki, et al.
Publicado: (2017)

Zinc Protects Articular Chondrocytes through Changes in Nrf2-Mediated Antioxidants, Cytokines and Matrix Metalloproteinases
por: Huang, Tzu-Ching, et al.
Publicado: (2018)

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis
por: Sahlender, Daniela A., et al.
Publicado: (2005)

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection
por: Mankouri, Jamel, et al.
Publicado: (2010)

Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma Gene
por: Ying, Hongyu, et al.
Publicado: (2010)

Effects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cells
por: Li, Hongyang, et al.
Publicado: (2011)

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
por: Ying, Hongyu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_l6lqsoc8b306470u29v9q9aqlg